Photolabile Scaffolds for Molecular Recognition

本研究的重点是在合成有机化学、分子识别和超分子光化学领域成功发展的跨学科项目的延续。该研究旨在开发一种高效的模块化合成方法，通过光致分子连接剂组装各种复杂的多单元纳米级物体，从而能够光诱导拆卸。核心是最近发展的光电子转移诱导的取代-羟基烷基二硫烷及其相关化合物家族的裂解。其次，利用这些光锁，该小组将开发出具有分子识别元素的新型光致纳米级物体，可用于生物应用。具体来说，第二个目标将包括以下两个一般方向：(i)自组装光降解笼和胶囊，（ii）在外部敏化的光裂解连接物中进行光化学扩增，用于固体载体组合筛选。有了这个奖项，有机和大分子化学项目支持丹佛大学化学系的Andrei G. Kutateladze博士的研究和教育工作。库塔泰拉泽教授将把他的研究重点放在开发含有光可切割纳米颗粒的新材料上。这可能对超分子有机光化学和分子识别原理的基本理解产生重要影响，这项研究的结果也将对应用生物医学科学产生更广泛的影响，包括药物发现和药物输送。

The focus of this research is continuation of a successfully-developing cross-disciplinary program in synthetic organic chemistry, molecular recognition and supramolecular photochemistry. The research aims to develop an efficient modular synthetic approach to a variety of elaborate multi-unit nanoscale objects assembled with the aid of photolabile molecular linkers and, therefore, capable of photoinduced disassembly. At the core is the recently developed photo electron transfer-induced cleavage in substituted alpha-hydroxyalkyl dithiane and a family of related compounds. Secondly, utilizing these photo-latches this group will develop novel photolabile nanoscale objects equipped with elements of molecular recognition that can be used in biological applications. Specifically, the second goal will encompass the following two general directions: (i) self-assembled photolabile cages and capsules, (ii) photochemical amplification in externally sensitized photocleavable linkers for solid support combinatorial screening.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research and educational efforts of Dr. Andrei G. Kutateladze of the Department of Chemistry at the University of Denver, Denver. Professor Kutateladze will focus his research on the development of new materials containing photo-cleavable nanoparticles. This could have important ramifications in the fundamental understanding of the principles governing supramolecular organic photochemistry and molecular recognition, the results of this research will also have broader implications for applied biomedical sciences, including drug discovery and drug delivery.