Photolabile Scaffolds for Molecular Recognition

用于分子识别的不耐光支架

• 批准号: 0314344
• 负责人: Andrei Kutateladze
• 金额: $ 33.6万
• 依托单位: University of Denver
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0314344&HistoricalAwards=false
• 关键词: Photolabile; Scaffolds; Molecular; Recognition

The focus of this research is continuation of a successfully-developing cross-disciplinary program in synthetic organic chemistry, molecular recognition and supramolecular photochemistry. The research aims to develop an efficient modular synthetic approach to a variety of elaborate multi-unit nanoscale objects assembled with the aid of photolabile molecular linkers and, therefore, capable of photoinduced disassembly. At the core is the recently developed photo electron transfer-induced cleavage in substituted alpha-hydroxyalkyl dithiane and a family of related compounds. Secondly, utilizing these photo-latches this group will develop novel photolabile nanoscale objects equipped with elements of molecular recognition that can be used in biological applications. Specifically, the second goal will encompass the following two general directions: (i) self-assembled photolabile cages and capsules, (ii) photochemical amplification in externally sensitized photocleavable linkers for solid support combinatorial screening.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research and educational efforts of Dr. Andrei G. Kutateladze of the Department of Chemistry at the University of Denver, Denver. Professor Kutateladze will focus his research on the development of new materials containing photo-cleavable nanoparticles. This could have important ramifications in the fundamental understanding of the principles governing supramolecular organic photochemistry and molecular recognition, the results of this research will also have broader implications for applied biomedical sciences, including drug discovery and drug delivery.

这项研究的重点是在合成有机化学、分子识别和超分子光化学方面成功发展的跨学科项目的继续。这项研究旨在开发一种高效的模块化合成方法，利用光敏分子连接物组装各种精细的多单元纳米对象，从而能够进行光诱导拆解。核心是最近发展起来的光电子转移诱导取代的α-羟基烷二硫和一系列相关化合物的裂解。其次，利用这些光锁存，该团队将开发配备了可用于生物应用的分子识别元件的新型可光纳米物体。具体地说，第二个目标将包括以下两个总体方向：(I)自组装的可发光笼子和胶囊，(Ii)用于固体载体组合筛选的外部敏化可光裂解连接体的光化学放大。有了这个续展奖，有机和高分子化学计划正在支持丹佛大学化学系的Andrei G.Kutateladze博士的研究和教育工作。Kutateladze教授将把他的研究重点放在开发包含可光分解纳米颗粒的新材料上。这可能会对超分子有机光化学和分子识别原理的基本理解产生重要的影响，这项研究的结果也将对应用生物医学科学，包括药物发现和药物输送产生更广泛的影响。