CAREER: Synthetic Methodologies Based on Novel SET-Induced Cleavage in Hydroxyalkyl Dithianes

有了这个职业奖的有机和高分子化学计划支持博士安德烈G。丹佛大学化学和生物化学系的Kutateladze说。 他的研究旨在设计基于电子转移诱导的取代α-羟烷基二噻烷裂解的改进的有机合成方法。 这些二噻烷在复杂有机化合物的合成过程中，羰基（含两个硫原子的环状化合物）被用来保护羰基（C=O），并且具有易于被光去除的新颖性质。PI强烈主张将教育与研究相结合，并让学生参与各种研究活动，包括合成，光化学和光物理，核磁共振，材料科学，理论化学和计算机编程 他的教育活动根据这项补助金，包括开发一个大一/大二水平的有机课程和两个先进的课程，利用多媒体，计算机模拟/动画，和分子建模。 PI鼓励他的研究生参加当地的高中科学博览会，并将参加一个部门的夏季研究计划，为地区高中化学教师。

With this CAREER award the Organic and Macromolecular Chemistry Program supports the work of Dr. Andrei G. Kutateladze of the Department of Chemistry and Biochemistry at the University of Denver. His research is aimed at designing improved organic synthetic methods based on electron transfer- induced cleavage of substituted alpha-hydroxyalkyl dithianes. These dithianes (cyclic compounds containing two sulfur atoms) are used to protect carbonyl groups (C=O) during the synthesis of complex organic compounds, and have the novel property of being readily removed with light.The PI believes strongly in integrating education and research, and involves students in a wide variety of research activities including synthesis, photochemistry and photophysics, nuclear magnetic resonance, materials science, theoretical chemistry, and computer programming. His educational activities under this grant include developing one freshman/sophomore level organic course and two advanced courses, utilizing multimedia, computer simulation/animation, and molecular modeling. The PI encourages his graduate students to participate in local high school Science Fairs, and will participate in a departmental summer research program for area high school chemistry teachers.