CAREER: Synthetic Methodologies Based on Novel SET-Induced Cleavage in Hydroxyalkyl Dithianes

通过这一职业奖，有机和高分子化学项目支持丹佛大学化学和生物化学系Andrei G.Kutateladze博士的工作。他的研究旨在设计基于电子转移诱导取代的α-羟基烷基二硫烷裂解的改进的有机合成方法。这些二硫杂环化合物(含两个硫原子的环状化合物)在合成复杂有机化合物的过程中被用来保护羰基(C=O)，并具有用光容易去除的新颖性质。PI坚定地相信教育和研究的结合，并让学生参与广泛的研究活动，包括合成、光化学和光物理、核磁共振、材料科学、理论化学和计算机编程。他在这笔赠款下的教育活动包括开发一门一年级/二年级的有机课程和两门高级课程，利用多媒体、计算机模拟/动画和分子建模。PI鼓励他的研究生参加当地的高中科学博览会，并将参加一个面向地区高中化学教师的部门暑期研究计划。

With this CAREER award the Organic and Macromolecular Chemistry Program supports the work of Dr. Andrei G. Kutateladze of the Department of Chemistry and Biochemistry at the University of Denver. His research is aimed at designing improved organic synthetic methods based on electron transfer- induced cleavage of substituted alpha-hydroxyalkyl dithianes. These dithianes (cyclic compounds containing two sulfur atoms) are used to protect carbonyl groups (C=O) during the synthesis of complex organic compounds, and have the novel property of being readily removed with light.The PI believes strongly in integrating education and research, and involves students in a wide variety of research activities including synthesis, photochemistry and photophysics, nuclear magnetic resonance, materials science, theoretical chemistry, and computer programming. His educational activities under this grant include developing one freshman/sophomore level organic course and two advanced courses, utilizing multimedia, computer simulation/animation, and molecular modeling. The PI encourages his graduate students to participate in local high school Science Fairs, and will participate in a departmental summer research program for area high school chemistry teachers.