CAREER: Research and Education in Ambient Mass Spectrometry with Applications in Counterfeit Drug Detection.

职业：环境质谱的研究和教育及其在假药检测中的应用。

• 批准号: 0645094
• 负责人: Facundo Fernandez
• 金额: $ 55万
• 依托单位: Georgia Tech Research Corporation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-15 至 2013-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0645094&HistoricalAwards=false
• 关键词: CAREER; Research; Education; Ambient; Mass

This CAREER award funded by the Analytical and Surface Chemistry program in the Chemistry Division supports work by Professor Facundo Fernandez at the Georgia Institute of Technology to study and optimize the mechanisms of ion production in ambient ionization techniques for mass spectrometry (MS), with applications for rapid screening and fingerprinting of drugs in the open air. Screening will aim at detection of counterfeit and/or substandard drugs. Improved fundamental understanding of ambient ionization methods will enable development of better detection techniques to characterize different types of counterfeit drugs, and to combat and prevent this problem. More broadly, the work will support more rational application of ambient MS sampling techniques in a wide range of potential applications.Professor Fernandez intends to promote increased awareness of fake drugs by guiding high school teachers in the development of field colorimetric tests and basic chemical separation experiments with pharmaceuticals, which will be used later by Hispanic high school students during "Summer Research Camps" at Georgia Tech. He will create teaching materials and will pursue a set of unconventional activities designed to increase the level of awareness regarding the existence of counterfeit drugs. Activities will include traveling seminars on "Case Stories on Drug Counterfeiting" for the medical community, a web-based information repository to distribute DESI chemical fingerprints, and a graduate-level course with hands-on analytical work with fake drugs. These activities and efforts in developing new laboratory-based screening methods will benefit from a local collaboration with experts from the Geographical Information Systems (GIS) Center at Georgia Tech.

由化学部分析和表面化学计划资助的职业奖支持Facundo费尔南德斯教授在格鲁吉亚理工学院的工作，以研究和优化质谱（MS）环境电离技术中离子产生的机制，并应用于露天药物的快速筛选和指纹识别。 筛查的目的是发现假冒和/或劣质药品。 提高对环境电离方法的基本理解将有助于开发更好的检测技术，以表征不同类型的假药，并打击和预防这一问题。 更广泛地说，这项工作将支持更合理的应用环境质谱采样技术在广泛的潜在应用。教授费尔南德斯打算促进提高认识的假药，指导高中教师在发展领域的比色测试和基本的化学分离实验与药品，这将用于稍后的西班牙裔高中学生在“夏季研究营”在格鲁吉亚技术。 他将编写教材，并将开展一系列非常规活动，以提高人们对假药存在的认识。 活动将包括为医学界举办的关于“药品伪造案例”的巡回研讨会、一个基于网络的信息库，以分发DESI化学指纹，以及一个研究生水平的课程，其中包括对假药的实际分析工作。 这些开发新的实验室筛查方法的活动和努力将受益于与格鲁吉亚理工学院地理信息系统（GIS）中心专家的当地合作。