MRI: Development of an Atmospheric Pressure Ion Mobility Quadrupole Time-of-flight Mass Spectrometer for Ambient Imaging

MRI：开发用于环境成像的大气压离子淌度四极杆飞行时间质谱仪

• 批准号: 0923179
• 负责人: Facundo Fernandez
• 金额: $ 80万
• 依托单位: Georgia Tech Research Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0923179&HistoricalAwards=false
• 关键词: MRI; Development; Atmospheric; Pressure; Ion

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Major Research Instrumentation (MRI) program, Facundo Fernandez and colleagues Thomas Orlando, Mark Sullards and Dongmei Wang from Georgia Institute of Technology will develop an atmospheric pressure ion mobility mass spectrometer for ambient imaging. The proposed imaging mass spectrometer will combine ambient ion sources with ion-mobility and hybrid quadrupole time-of-flight mass analyzers to achieve improved chemical separation. The proposed mass spectrometer will be used to do chemical imaging in a number of research projects, from the study of chemical defenses in marine algae to the detection of counterfeit pharmaceuticals. The project will be carried out by a diverse group of young scientists, ranging from the high-school to postdoctoral level.Mass Spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species embedded in complex matrices. Imaging mass spectrometry is a new application, whereby, species are collected from a material's surface and chemically analyzed. In this way, a chemically-specific photograph of an object can be obtained. Scientists may use the photograph to determine details of biological or chemical processes in intact samples, with only minimal perturbation. The young scientists working with Fernandez and colleagues will obtain first-hand experience in instrument development -- a critical skill for a technologically-driven society.

该奖项是根据2009年《美国复苏与再投资法案》(Public Law 111-5)资助的。在重大研究仪器(MRI)项目的资助下，佐治亚理工学院的Facundo Fernandez及其同事Thomas Orlando、Mark Sullards和Donmei Wang将开发用于大气成像的大气压离子迁移质谱计。拟议的成像质谱仪将结合周围的离子源、离子迁移率和混合四极杆飞行时间质谱仪，以实现改进的化学分离。拟议中的质谱仪将用于一系列研究项目的化学成像，从研究海藻的化学防御到检测假药。该项目将由不同的年轻科学家群体进行，从高中到博士后水平。质谱学(MS)是用于识别和表征嵌入复杂基质中的少量化学物种的关键分析方法之一。成像质谱学是一种新的应用，它从物质的表面收集物种并进行化学分析。通过这种方式，可以获得对象的化学特定照片。科学家可以使用这张照片来确定完整样本中的生物或化学过程的细节，只有最小的干扰。与费尔南德斯及其同事合作的年轻科学家将获得仪器开发方面的第一手经验--这是一个技术驱动的社会的一项关键技能。