CAREER: Self-Assembly of Electrophilic Late Metal Catalysts and Catalyzing Careers in Research

职业：亲电晚金属催化剂的自组装和研究催化职业

• 批准号: 0645438
• 负责人: LeGrande Slaughter
• 金额: $ 56万
• 依托单位: Oklahoma State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0645438&HistoricalAwards=false
• 关键词: CAREER; Self; Assembly; Electrophilic; Late

This CAREER award by the Inorganic, Bioinorganic and Organometallic Chemistry program supports work by Professor LeGrande Slaughter at Oklahoma State University to investigate a unique type of self-assembly based on metallo-click reactivity of metal-bound isocyanides. Novel synthetic methods are used to construct a diverse array of diaminocarbene ligands with varying electron-donating properties and chiral structures. These ligands will be systematically modified to discover and optimize Lewis acidic late-metal catalysts for chiral [3,3]-sigmatropic rearrangements and Nazarov cyclizations, synthetically valuable reactions for which conventional ligands are not broadly effective. New tools for the conversion of inexpensive, readily available precursors into medicinally important complex molecules are an anticipated outcome of this research. A focus on catalyst discovery will link this research with an educational outreach program targeting rural high school students. In partnership with an existing Upward Bound program, students from rural schools that have high percentages of American Indian students and students from families with no history of college education will be recruited for participation in two interrelated activities. First, a series of experiments entitled Catalyzing Discovery will introduce students to the excitement of research through hands-on experimentation involving catalysis. Second, Web-based Cyberspace Research Summits (CReS) will emphasize the broader impacts of basic research through interactive cyber-enabled videoconferences that bring students together with industrial and academic catalysis researchers. The ultimate goal of this program is to increase attainment of research careers by rural students, positively impacting both their communities and the scientific workforce.

该职业奖由无机、生物无机和有机金属化学项目颁发，支持俄克拉荷马州立大学 LeGrande Slaughter 教授的工作，研究基于金属结合异氰化物的金属点击反应性的独特类型的自组装。 采用新颖的合成方法来构建具有不同给电子特性和手性结构的多种二氨基卡宾配体。 这些配体将被系统地修饰，以发现和优化用于手性[3,3]-σ重排和纳扎罗夫环化的路易斯酸性后金属催化剂，这些反应具有合成价值，而传统配体不能广泛有效。 将廉价、容易获得的前体转化为医学上重要的复杂分子的新工具是这项研究的预期成果。 对催化剂发现的关注将把这项研究与针对农村高中生的教育推广计划联系起来。 与现有的 Upward Bound 计划合作，来自美洲印第安人学生比例较高的农村学校的学生和来自没有大学教育背景的家庭的学生将被招募参加两项相互关联的活动。 首先，一系列题为“催化发现”的实验将通过涉及催化的动手实验向学生介绍研究的乐趣。 其次，基于网络的网络空间研究峰会（CReS）将通过交互式网络视频会议强调基础研究的更广泛影响，将学生与工业和学术催化研究人员聚集在一起。 该计划的最终目标是提高农村学生的研究职业成就，对他们的社区和科学劳动力产生积极影响。