CAREER: Voltammetric Ion-Selective Electrode for Biological Polyions and Beyond

职业：用于生物聚离子及其他领域的伏安离子选择电极

• 批准号: 0645623
• 负责人: Shigeru Amemiya
• 金额: $ 55.94万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2013-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0645623&HistoricalAwards=false
• 关键词: CAREER; Voltammetric; Ion; Selective; Electrode

Professor Shigeru Amemiya of the University of Pittsburgh has received a CAREER Award from the Analytical and Surface Chemistry Program to develop voltammetric ion-selective electrodes (ISEs) for biological polyions and other redox-inactive ions, which are ubiquitous and important in biological and environmental media. Double polymer membranes based on an ion-selective polymer and a conjugated conducting polymer will be created on a solid electrode. A current response will be controlled by ion transfer at the interface between the ion-selective membrane and the aqueous sample solution. The conducting polymer will serve as an intermediate layer to efficiently mediate charge transport between the ionically conductive membrane and the electronically conductive solid support. The ionic current response will be idealistic for monitoring biomedically important polyions such as anticoagulant/antithrombotic heparin and its antidote protamine in their narrow and low therapeutic concentration ranges. The chemical basis of selectivity, detection limit, and biocompatibility in these solid-supported voltammetric ISEs will be explored, as well as strategies for miniaturization and incorporation into microfluidic devices. The PI will integrate research and teaching programs by directly implementing research outcomes into teaching curricula. Voltammetric ISEs will be developed also as a shared educational tool to address the emerging environmental problem of perchlorate contamination in undergraduate laboratory. The PI will introduce COMSOL Multiphysics as a powerful simulation tool to enhance students' ability to understand computationally intense problems in chemistry.Information obtained from the research will enhance our knowledge and understanding in the areas of chemical sensors, electrochemistry, molecular recognition, and polymer chemistry. The voltammetric ISEs have potential for wide use in biomedical, biological, and environmental analyses. The PI will take advantage of the interdisciplinary approach to widen research participation of undergraduates, women, and underrepresented minorities.

匹兹堡大学的Shigeru Amemiya教授获得了分析和表面化学计划的职业奖，为生物聚离子和其他氧化还原惰性离子开发伏安离子选择性电极（ISE），这些离子在生物和环境介质中无处不在且重要。基于离子选择性聚合物和共轭导电聚合物的双聚合物膜将在固体电极上产生。电流响应将通过离子选择性膜和样品水溶液之间界面处的离子转移来控制。导电聚合物将用作中间层以有效地介导离子导电膜和电子导电固体载体之间的电荷传输。离子电流响应将是理想的监测生物医学上重要的聚离子，如抗凝/抗血栓肝素及其解毒剂鱼精蛋白在其狭窄和低的治疗浓度范围。将探讨这些固体支持伏安ISE的选择性，检测限和生物相容性的化学基础，以及微型化和纳入微流体装置的策略。PI将通过直接将研究成果纳入教学课程来整合研究和教学计划。伏安离子选择电极也将被开发为一种共享的教育工具，以解决大学生实验室中高氯酸盐污染的新环境问题。PI将介绍COMSOL Multiphysics作为一个强大的模拟工具，以提高学生理解化学计算密集型问题的能力。从研究中获得的信息将增强我们在化学传感器，电化学，分子识别和聚合物化学领域的知识和理解。伏安离子选择电极在生物医学、生物学和环境分析中具有广泛的应用前景。PI将利用跨学科的方法来扩大本科生，妇女和代表性不足的少数民族的研究参与。