A universal palladium precatalyst for efficient chemical synthesis of molecules and materials

用于高效化学合成分子和材料的通用钯预催化剂

• 批准号: 561560-2021
• 负责人: Leitch, David
• 金额: $ 9.11万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=724260
• 关键词: universal; palladium; precatalyst; efficient; chemical

Catalysis is an enabling technology in chemical synthesis, providing the means to efficiently prepare new molecules and materials with applications ranging from solar energy harvesting to human health. Palladium-catalyzed cross-coupling is among the most powerful and widely used catalytic methods, particularly in industrial R&D to create new pharmaceuticals, agrochemicals, and organic materials. A significant challenge in applying palladium catalysis to synthesize complex molecular targets is identifying the appropriate combination of palladium source and supporting additives; industrial research groups will literally perform thousands of experiments to tackle this problem. A second major challenge is to achieve high chemical yield of the desired product on large scale while minimizing the cost of goods. For palladium catalyzed processes, this is often a delicate balance between maximizing efficiency and minimizing the catalyst amount.Our research group recently reported a robust and active family of palladium catalysts for achieving the formation of carbon-carbon, carbon-nitrogen, and carbon-oxygen bonds. This set of catalysts was designed specifically to enable and accelerate high-throughput screening for reaction discovery, and also to be user-friendly during scale-up and process optimization. This proposal seeks to bridge the divide between our fundamental, laboratory-scale insights to turn this discovery into a practical and commercialized solution for the synthesis and manufacture of new molecules and materials. Ultimately, this will help drive down the cost of medicines and green energy devices by reducing the cost of goods/manufacture.

催化是化学合成中的一种使能技术，提供了有效制备新分子和材料的方法，其应用范围从太阳能收集到人类健康。钯催化的交叉偶联是最强大和最广泛使用的催化方法之一，特别是在工业研发中，以创造新的药物，农用化学品和有机材料。应用钯催化合成复杂分子目标的一个重大挑战是确定钯源和支持添加剂的适当组合;工业研究小组将进行数千次实验来解决这个问题。第二个主要挑战是大规模实现所需产品的高化学产率，同时使商品成本最小化。对于钯催化过程，这通常是最大化效率和最小化催化剂用量之间的微妙平衡。我们的研究小组最近报道了一个强大而活跃的钯催化剂家族，用于实现碳-碳，碳-氮和碳-氧键的形成。这套催化剂专门设计用于实现和加速反应发现的高通量筛选，并且在放大和工艺优化期间对用户友好。该提案旨在弥合我们基本的实验室规模的见解之间的鸿沟，将这一发现转化为合成和制造新分子和材料的实用和商业化解决方案。最终，这将有助于通过降低商品/制造成本来降低药品和绿色能源设备的成本。