GOALI: Macromolecular Design with Organocatalysis

该项目的目标是从有机分子中发现催化反应性的新模式，作为合成新型聚合物的可控聚合方法的实现者。 具体目标是：（1）开发新的两性离子策略以产生纯环状聚合物;（2）利用实验和理论方法来设计用于内酯和其它单体的活性开环聚合的高选择性有机催化剂;和（3）开发用于开环聚合和酯交换反应的新的胍催化剂。 有了这个奖项，有机和高分子化学计划是支持教授罗伯特M。斯坦福大学化学系的Waymouth博士和James L. IBM的赫德里克。 这个GOALI团队的研究工作围绕着开发新的策略，以创造新的可生物降解的聚合物类衍生自可再生资源。 这一目标的成功实现将减少社会对石化原料的依赖。 它还可能导致一类新的低k电介质材料。

The goal of this project is to discover new patterns of catalytic reactivity from organic molecules as an enabler of controlled polymerization methods for the synthesis of novel polymers. Specific objectives are to: (1) develop novel zwitterionic strategies to generate purely cyclic polymers; (2) utilize experimental and theoretical methods to design highly selective organocatalysts for the living ring-opening polymerization of lactones and other monomers; and (3) exploit novel guanidine catalysts for ring-opening polymerization and transesterification reactions. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Robert M. Waymouth, of the Department of Chemistry at Stanford University and Dr. James L. Hedrick at IBM. The research efforts of this GOALI team revolve around the development of new strategies for creating new classes of biodegradable polymers derived from renewable resources. Successful accomplishment of this goal will reduce the societal dependence on petrochemical feedstock. It could also lead to a new class of low-k dielectric materials.