GOALI: Macromolecular Design with Organocatalysis

该项目的目标是从有机分子中发现新的催化反应性模式，作为合成新型聚合物的受控聚合方法的促进剂。具体目标是：(1)开发新的两性离子策略来生成纯环状聚合物；(2)利用实验和理论方法设计高选择性的有机催化剂，用于内酯和其他单体的活性开环聚合；以及(3)开发用于开环聚合和酯交换反应的新型胍催化剂。通过这个奖项，有机和高分子化学项目支持斯坦福大学化学系的罗伯特·M·韦茅斯教授和IBM的詹姆斯·L·海德里克博士的研究。这个Goali团队的研究努力围绕着开发新的战略，以创造从可再生资源中提取的新型可生物降解聚合物。这一目标的成功实现将减少社会对石化原料的依赖。这也可能导致一类新的低k介电材料。

The goal of this project is to discover new patterns of catalytic reactivity from organic molecules as an enabler of controlled polymerization methods for the synthesis of novel polymers. Specific objectives are to: (1) develop novel zwitterionic strategies to generate purely cyclic polymers; (2) utilize experimental and theoretical methods to design highly selective organocatalysts for the living ring-opening polymerization of lactones and other monomers; and (3) exploit novel guanidine catalysts for ring-opening polymerization and transesterification reactions. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Robert M. Waymouth, of the Department of Chemistry at Stanford University and Dr. James L. Hedrick at IBM. The research efforts of this GOALI team revolve around the development of new strategies for creating new classes of biodegradable polymers derived from renewable resources. Successful accomplishment of this goal will reduce the societal dependence on petrochemical feedstock. It could also lead to a new class of low-k dielectric materials.