GOALI: Macromolecular Design with Organocatalysis

该项目的目标是发现有机分子催化反应的新模式，作为合成新型聚合物的可控聚合方法的推动者。具体目标是：(1)开发新的两性离子策略来生成纯环状聚合物；(2)利用实验和理论方法设计高选择性的有机催化剂，用于内酯和其他单体的开环活聚合；(3)开发用于开环聚合和酯交换反应的新型胍类催化剂。通过这个奖项，有机和大分子化学项目支持了斯坦福大学化学系的Robert M. Waymouth教授和IBM公司的James L. Hedrick博士的研究。GOALI团队的研究工作围绕着开发新策略，以创造来自可再生资源的新型可生物降解聚合物。这一目标的成功实现将减少社会对石化原料的依赖。它还可能导致一种新的低k介电材料。

The goal of this project is to discover new patterns of catalytic reactivity from organic molecules as an enabler of controlled polymerization methods for the synthesis of novel polymers. Specific objectives are to: (1) develop novel zwitterionic strategies to generate purely cyclic polymers; (2) utilize experimental and theoretical methods to design highly selective organocatalysts for the living ring-opening polymerization of lactones and other monomers; and (3) exploit novel guanidine catalysts for ring-opening polymerization and transesterification reactions. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Robert M. Waymouth, of the Department of Chemistry at Stanford University and Dr. James L. Hedrick at IBM. The research efforts of this GOALI team revolve around the development of new strategies for creating new classes of biodegradable polymers derived from renewable resources. Successful accomplishment of this goal will reduce the societal dependence on petrochemical feedstock. It could also lead to a new class of low-k dielectric materials.