GOALI: Organocatalytic Polymerization: New Synthetic Methods for Polymer Chemistry

目标：有机催化聚合：高分子化学的新合成方法

• 批准号: 0957386
• 负责人: Robert Waymouth
• 金额: $ 51万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0957386&HistoricalAwards=false
• 关键词: GOALI; Organocatalytic; Polymerization; New; Synthetic

The Chemical Catalysis Program supports Professor Robert M. Waymouth at Stanford University and Dr. James L Hedrick at IBM for a research project that will explore new patterns of reactivity of organic catalysts for controlled polymerization reactions. Specific objectives are to: (1) develop novel bifunctional strategies for organocatalytic polymerization reactions; (2) develop a detailed kinetic and mechanistic understanding of zwitterionic polymerizations for the synthesis of macrocyclic polymers; and (3) develop new organocatalytic methods for the synthesis of biodegradable and biocompatible polyphosphates. The zwitterionic polymerization mediated by N-heterocyclic carbenes is a new conceptual advance for the enchainment of monomers to high molecular weight cyclic polymers. Mechanistic and kinetic insights on the details of these reactions will provide a conceptual and quantitative picture of the scope, power and limitations of this new synthetic method. Organocatalytic polymerization strategies provide an environmentally friendly approach for the synthesis and recycling of major commodity polymers. Mechanistic insights on new mechanisms of enchainment will create new opportunities for the generation of novel polymer architectures, including new families of polyphosphates for biomedical applications.With the support of the Chemical Catalysis Program in the Chemistry Division at the National Science Foundation, Drs. Waymouth and Hedrick will perform research that will provide new catalytic strategies for the design of biodegradable polymers derived from renewable resources. New synthetic methods developed as part of this program will enable new strategies for the synthesis of well-defined polymer architectures. These developments will enable studies of the role of polymer structure on properties and function, issues that are fundamental to our understanding of chemistry and to the application of macromolecules in modern technologies. Broader impacts include involving students in an exceptional training environment involving a highly interdisciplinary and collaborative effort between an academic institution and an industrial laboratory. The PIs have taken an active role in recruiting and mentoring underrepresented minorities and disabled students. In addition, IBM is committing significant resources to this effort, including laboratory and office space for a postdoctoral coworker and visiting Stanford students, materials and supplies, extensive access to IBM facilities and infrastructure as well as 25% of Dr. Hedrick's time.

化学催化计划支持教授罗伯特M。斯坦福大学的Waymouth和IBM的James L赫德里克博士的研究项目，该项目将探索用于受控聚合反应的有机催化剂的反应性的新模式。具体目标是：（1）开发新的有机催化聚合反应的双功能策略;（2）开发一个详细的动力学和两性离子聚合的大环聚合物的合成机理的理解;和（3）开发新的有机催化方法的合成生物降解和生物相容性的聚磷酸盐。氮杂环卡宾介导的两性离子聚合是单体环化合成高分子环状聚合物的一个新概念。这些反应的细节机制和动力学的见解将提供一个概念和定量的范围，功率和这种新的合成方法的局限性的图片。有机催化聚合策略为主要商品聚合物的合成和回收提供了一种环境友好的方法。对新的连接机制的机理见解将为新的聚合物结构的产生创造新的机会，包括用于生物医学应用的新的聚磷酸盐家族。在美国国家科学基金会化学部化学催化计划的支持下，Waymouth和赫德里克博士将进行研究，为设计可生物降解的聚合物提供新的催化策略，这些聚合物来自可再生能源。资源作为该计划的一部分开发的新合成方法将使合成明确定义的聚合物结构的新策略成为可能。这些发展将使研究聚合物结构对性能和功能的作用成为可能，这些问题对于我们理解化学和现代技术中大分子的应用至关重要。更广泛的影响包括让学生参与特殊的培训环境，涉及学术机构和工业实验室之间的高度跨学科和协作努力。私人侦探在招募和指导代表性不足的少数民族和残疾学生方面发挥了积极作用。此外，IBM还为这项工作投入了大量资源，包括为博士后同事和来访的斯坦福大学学生提供实验室和办公空间、材料和用品、广泛使用IBM设施和基础设施以及赫德里克博士25%的时间。