New Catalysts and Methods for Stereoselective Carbocyclization

本研究的具体目的是开发新的催化和对映选择性环化方法，考察茂锆催化的二烯与二烷基镁试剂环合反应的范围和选择性，研究该催化体系可以容忍的官能团范围，并开发用于环金属反应的新型手性钽催化剂。通过这一奖项，合成有机计划支持斯坦福大学化学系罗伯特·M·韦茅斯博士的研究。韦茅斯教授将致力于开发使用过渡金属进行立体和对映选择性构筑多环环的催化方法。许多抗肿瘤、抗生素和抗真菌药物都是手性的，含有多环环。有效地合成具有这些结构亚基的纯对映体纯分子仍然是有机合成的一个艰巨但核心的挑战。

The specific aims of this research are to develop novel catalytic and enantioselective cyclization methods, to investigate the scope and selectivity of zirconocene-mediated cyclometallation of dienes with dialkylmagnesium reagents, to study the range of functionality that can be tolerated by this catalyst system and to develop new chiral tantalum catalysts for cyclometallation reactions. With this award, the Synthetic Organic Program supports the research of Dr. Robert M. Waymouth of the Department of Chemistry at Stanford University. Professor Waymouth will focus his work on developing catalytic methods for the stereo- and enantioselective construction of polycyclic rings using transition metals. Many antitumor, antibiotic and antifungal agents are chiral and contain polycyclic rings. Efficient synthesis of enantiomerically pure pure molecules with these structural subunits remains a formidable but central challenge to organic synthesis