Macromolecular design for bio-imaging and targeted delivery

用于生物成像和靶向递送的大分子设计

• 批准号: FL140100052
• 负责人: Prof Thomas Davis
• 金额: $ 167.24万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Australian Laureate Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FL140100052
• 关键词: Macromolecular; design; bio; imaging; targeted

Macromolecular design for bio-imaging and targeted delivery. A thorough understanding of how nanoparticles interact with biological systems is imperative if advances are to be made in using nanotechnology for therapeutic applications. Fundamental aspects of nanoparticle transport, targeting and cell uptake will be investigated. This project aims to design novel nanoparticulate systems for the delivery of both an endogenous signalling molecule and genes to cells. The project aims to inform future optimal design criteria for bespoke nanoparticle delivery systems.

用于生物成像和靶向递送的高分子设计。如果要在使用纳米技术进行治疗应用方面取得进展，就必须彻底了解纳米颗粒如何与生物系统相互作用。 纳米粒子的运输，靶向和细胞摄取的基本方面将进行研究。 该项目旨在设计新型纳米颗粒系统，用于将内源性信号分子和基因传递到细胞。 该项目旨在为定制纳米颗粒输送系统的未来最佳设计标准提供信息。