Collaborative Research: A Post-Genomic Approach to Synechococcus-grazer Interactions
合作研究:聚球藻-食草动物相互作用的后基因组方法
基本信息
- 批准号:0648572
- 负责人:
- 金额:$ 25.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-03-15 至 2011-02-28
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The most common fate of microbes in aquatic environments is to become a meal for a protest grazer. A major flux of carbon in aquatic environments is thus mediated through microbe-protist interactions. The mechanisms by which microbes attempt to avoid grazers likely include morphological, behavioral, and chemical resistance strategies, yet our knowledge of these is primitive and most progress is currently being made on harmful algal bloom species. One of the insights from the availability of multiple cyanobacterial genomes is that different cyanobacteria have very different cell surface structures as well as potentially different modifications of common structures. In addition, potential chemical resistance strategies have been detected in several available genomes. This project will address protest-cyanobacterial interactions with the collaboration of researchers with expertise in protist biology, cyanobacterial ecology, molecular genetics and genomics to examine the range of interactions between protists and cyanobacteria of the genus Synechococcus. The investigators propose to use the recent availability of complete genomes and molecular genetics tools to determine the key cell structures under selection by diverse protist grazers. They will use "shot-gun" approaches (transposon mutagenesis and selection) to identify these structures and use available mutants to investigate specific known cell surface structures. They will also examine the role of some potential chemical defense enzymes, found through whole genome comparisons, in deterring grazing. The proposed research will provide qualitative and quantitative information on the role of various grazer deterrence strategies and new paradigms for understanding grazer-prey interactions.Broader Impacts of the Proposed ResearchThe broader impacts of this work will include the training of undergraduate and graduate students, including those from under-represented groups. Scientific findings will be disseminated broadly though participation in national meetings and publication in peer-review journals. The findings may indicate a mechanistic basis for understanding microbe-grazer interactions, one of the major processes determining carbon cycling in the oceans. The investigators expect to define one or more model but ecologically relevant grazer-cyanobacteria pairs that could be used by the community for future studies. In addition, novel marine natural products that affect eukaryotic cells, with possible biotechnological applications, may be found through these activities.
水生环境中微生物最常见的命运是成为抗议食草动物的食物。因此,水生环境中的主要碳通量是通过微生物-原生生物相互作用介导的。微生物试图避开食草动物的机制可能包括形态、行为和化学抗性策略,但我们对这些的了解还很原始,目前大多数进展都是在有害藻华物种方面取得的。从多个蓝藻基因组的可用性中得出的见解之一是,不同的蓝藻具有非常不同的细胞表面结构以及对常见结构的潜在不同修饰。此外,在几个可用的基因组中还检测到了潜在的化学抗性策略。该项目将与具有原生生物、蓝藻生态学、分子遗传学和基因组学专业知识的研究人员合作,解决抗议-蓝藻相互作用问题,以研究原生生物和聚球藻属蓝藻之间的相互作用范围。研究人员建议利用最近可用的完整基因组和分子遗传学工具来确定不同原生食草动物选择下的关键细胞结构。他们将使用“鸟枪”方法(转座子诱变和选择)来识别这些结构,并使用可用的突变体来研究特定的已知细胞表面结构。他们还将研究通过全基因组比较发现的一些潜在化学防御酶在阻止放牧方面的作用。拟议的研究将提供有关各种食草动物威慑策略的作用和理解食草动物与猎物相互作用的新范式的定性和定量信息。拟议研究的更广泛影响这项工作的更广泛影响将包括对本科生和研究生的培训,包括来自代表性不足群体的学生。科学发现将通过参加国家会议和在同行评审期刊上发表来广泛传播。这些发现可能为理解微生物与食草动物的相互作用提供了机制基础,这是决定海洋碳循环的主要过程之一。研究人员希望定义一个或多个模型,但生态相关的食草动物-蓝藻对,可供社区用于未来的研究。此外,通过这些活动可能会发现影响真核细胞的新型海洋天然产物,并可能具有生物技术应用。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Suzanne Strom其他文献
Preoperative evaluation, premedication, and induction of anesthesia in infants and children.
婴儿和儿童的术前评估、术前用药和麻醉诱导。
- DOI:
- 发表时间:
2012 - 期刊:
- 影响因子:0
- 作者:
Suzanne Strom - 通讯作者:
Suzanne Strom
Commentaries on ‘Non‐pharmacological interventions for assisting the induction of anaesthesia in children’ with a response by the review authors
关于“辅助儿童麻醉诱导的非药物干预”的评论以及综述作者的回应
- DOI:
10.1002/ebch.671 - 发表时间:
2011 - 期刊:
- 影响因子:0
- 作者:
Z. Kain;Suzanne Strom;Jarmila Kim;W. Splinter;A. Cyna - 通讯作者:
A. Cyna
Teaching and Learning in Medicine : An International
医学教学:国际化
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:0
- 作者:
M. I. Langdorf;Suzanne Strom;Luanna Yang;Cecilia Canales;Craig L Anderson;Alpesh Amin;S. Lotfipour - 通讯作者:
S. Lotfipour
Suzanne Strom的其他文献
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{{ truncateString('Suzanne Strom', 18)}}的其他基金
FSML: A culture facility for small marine organisms at Shannon Point Marine Center
FSML:香农角海洋中心的小型海洋生物养殖设施
- 批准号:
2014617 - 财政年份:2020
- 资助金额:
$ 25.28万 - 项目类别:
Standard Grant
Environmental stress and signaling based on reactive oxygen species among planktonic protists
基于浮游原生生物活性氧的环境应激和信号传导
- 批准号:
1434842 - 财政年份:2014
- 资助金额:
$ 25.28万 - 项目类别:
Standard Grant
Collaborative Research: Constitutive and Inducible Predation Defenses in Cyanobacteria
合作研究:蓝藻的组成型和诱导型捕食防御
- 批准号:
1021189 - 财政年份:2010
- 资助金额:
$ 25.28万 - 项目类别:
Continuing Grant
Collaborative Research: Global-Pan Regional Synthesis: End-to-end energy budgets for USGLOBEC regions
合作研究:全球-泛区域综合:USGLOBEC 区域的端到端能源预算
- 批准号:
0814397 - 财政年份:2008
- 资助金额:
$ 25.28万 - 项目类别:
Standard Grant
Collaborative Research: U.S. GLOBEC: NEP Phase IIIb-CGOA: Links between climate and planktonic food webs
合作研究:美国 GLOBEC:NEP 第三阶段 b-CGOA:气候与浮游食物网之间的联系
- 批准号:
0639093 - 财政年份:2006
- 资助金额:
$ 25.28万 - 项目类别:
Standard Grant
Collaborative Research: Are diatoms chemically or mechanically defended against protist grazers?
合作研究:硅藻是否通过化学或机械方式防御原生食草动物?
- 批准号:
0551436 - 财政年份:2006
- 资助金额:
$ 25.28万 - 项目类别:
Standard Grant
Collaborative Proposal: Cross-Shelf Transport and Post-Bloom New Production Near the Pribilof Islands
合作提案:普里比洛夫群岛附近的跨货架运输和花后新生产
- 批准号:
0323150 - 财政年份:2003
- 资助金额:
$ 25.28万 - 项目类别:
Standard Grant
Collaborative research: Investigation of a phytoplankton DMSP-based chemical defense system active against protist grazers
合作研究:研究基于浮游植物 DMSP 的针对原生食草动物的化学防御系统
- 批准号:
0324352 - 财政年份:2003
- 资助金额:
$ 25.28万 - 项目类别:
Standard Grant
GLOBEC 2000: Responses of the Neocalanus spp. - Microplankton Community to Physical forcing in the Coastal Gulf of Alaska
GLOBEC 2000:Neocalanus spp 的反应。
- 批准号:
0101397 - 财政年份:2001
- 资助金额:
$ 25.28万 - 项目类别:
Continuing Grant
Light-aided digestion of Phytoplankton Prey by Heterotrophic Protist Grazers
异养原生食草动物对浮游植物猎物的光辅助消化
- 批准号:
0002479 - 财政年份:2000
- 资助金额:
$ 25.28万 - 项目类别:
Continuing Grant
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