SGER: Self-Assembled Protein Nanostructures with Novel Functions

SGER：具有新功能的自组装蛋白质纳米结构

• 批准号: 0653773
• 负责人: Ruizhen Chen
• 金额: --
• 依托单位: Georgia Tech Research Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0653773&HistoricalAwards=false
• 关键词: SGER; Self; Assembled; Protein; Nanostructures

0653773ChenThis exploratory project is to develop self-assembled protein nanostructures with novel functions and seeks a basic understanding of the principles governing their design, self-assembly, stability, and functionality. Cellulosome, a multi-protein nanostructure (18 nm), is an active nanosystem naturally made by certain anaerobic microbes for assimilating recalcitrant cellulose. This self-assembled system brings multiple enzymes in the proximity of the substrate (cellulose) and provides a structure that ensures a high local concentration and correct ratio/orders of its components, thereby maximizing the synergy and enhancing the catalytic efficiency. This project is to use cellulosome as a design template to build novel and multifunctional protein nanostructures.

0653773 Chen这个探索性项目是开发具有新功能的自组装蛋白质纳米结构，并寻求对其设计，自组装，稳定性和功能性的基本理解。 纤维素体是一种多蛋白质纳米结构（18纳米），是由某些厌氧微生物天然产生的活性纳米系统，用于同化顽固纤维素。这种自组装系统将多种酶带到底物（纤维素）附近，并提供确保其组分的高局部浓度和正确比例/顺序的结构，从而使协同作用最大化并提高催化效率。本计画以纤维素酶体为设计模板，建构新颖且多功能的蛋白质奈米结构。