Integrating Sense of Direction in Cortical Control of Navigation

将方向感整合到导航的皮质控制中

• 批准号: 0702057
• 负责人: Jennie Si
• 金额: $ 30万
• 依托单位: Arizona State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0702057&HistoricalAwards=false
• 关键词: Integrating; Sense; Direction; Cortical; Control

Proposal Number: 0702057Proposal Title: Integrating Sense of Direction in Cortical Control of NavigationPI Name: Si, Jennie PI Institution: Arizona State UniversityThe objective of this research is to study a specific set of sensory motor integration tasks to gain fundamental understanding of cognition based navigational control. The approach is to chronically record from the anterior thalamic nucleus and the motor areas simultaneously in behaving rats. The proposed behavioral apparatus consists of a directionally controlled robotic vehicle which the rat can steer left, right, or straight ahead by pressing one of three corresponding levers. At the start of each trial, the vehicle is preset to move in a biased direction that requires a sequence of corrections from the rat's lever control to reach a destination. The proposed work also attempts at modeling and interpreting how neural information from sensory and motor areas interact and impact on one another in relation to the cognitive direction based navigational control. Intellectual merit. The ability to study neuronal mechanism of high order cognition has just become possible with technological advancement and the fast developing knowledge from relevant disciplines. The proposed research is a concrete step to break the ground toward an understanding of skilled movement that requires sophisticated sensory motor integration.Broader impacts. As most of the research has focused on specific cue-directed movements, the proposed work has the potential to break new ground and provide a cognitive perspective of the complex movement control systems with quantitative and neurophysiological evidence obtained through chronic neural recordings. New brain machine interfaces may become possible relying on cognition based navigation and control.

提案号：0702057提案标题：在导航皮层控制中整合方向感PI名称：Si， Jennie PI机构：亚利桑那州立大学本研究的目的是研究一组特定的感觉运动整合任务，以获得基于认知的导航控制的基本理解。该方法是对行为大鼠的丘脑前核和运动区同时进行慢性记录。提出的行为装置由一个方向控制的机器人车辆组成，老鼠可以通过按三个相应的杠杆之一来向左、向右或直线前进。在每次试验开始时，车辆都预先设定在一个有偏差的方向上移动，这需要大鼠的杠杆控制进行一系列修正才能到达目的地。提出的工作还试图建模和解释来自感觉和运动区域的神经信息如何在基于认知方向的导航控制中相互作用和相互影响。知识价值。随着技术的进步和相关学科知识的快速发展，研究高阶认知的神经元机制成为可能。这项提议的研究是为理解需要复杂感觉运动整合的熟练运动而迈出的具体一步。更广泛的影响。由于大多数研究都集中在特定的线索导向运动上，本研究有可能开辟新路，并通过慢性神经记录获得定量和神经生理学证据，为复杂的运动控制系统提供认知视角。依靠基于认知的导航和控制，新的脑机接口可能成为可能。