An Integrated View on Neural Correlates of Attention and Control

关于注意力和控制的神经相关性的综合观点

• 批准号: 1232298
• 负责人: Jennie Si
• 金额: $ 38.67万
• 依托单位: Arizona State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1232298&HistoricalAwards=false
• 关键词: Integrated; View; Neural; Correlates; Attention

The objective of this research to study how electrical activities in neuronal circuits give rise to intelligent control behaviors from perception to action. The approach is to first record behavioral and neurophysiological data from a rat while he performs a driving task. Subsequently the experimental data will be analyzed using spatiotemporal coding schemes and phase coherence techniques to unveil the correlation between neural cortical signals and behavior. The PI will perform multichannel chronic recordings from rat?s motor and premotor areas and posterior parietal cortex using a combination of Electrocorticography electrodes and depth electrodes for single unit activities. Intellectual merit. The proposed research is a systematic approach to addressing fundamental issues in relation to the integration of perception and control, neural coding/decoding, and the causal relationship between neural representations and intelligent behaviors. Broad impact. The proposed experiments are challenging and thus, results from these studies can be potentially ground breaking. This study is a part of the PI?s long term goal of pushing toward an understanding of natural and complex behaviors, which is a significant step forward from what are currently available in experimental and computational neuroscience. Fundamental discoveries from this research can provide important insights on nano-circuits designed to replace or provide remedy for deficient neural circuits in patients with perceptual-motor impairment. Graduate, undergraduate, and high school students, many of whom are female, have been and will continue to be involved in the research.

本研究的目的是研究神经回路中的电活动如何产生从感知到行动的智能控制行为。该方法首先记录老鼠在驾驶时的行为和神经生理数据。随后，实验数据将使用时空编码方案和相位相干技术进行分析，以揭示神经皮质信号与行为之间的相关性。PI将执行来自老鼠的多通道慢性记录。使用皮质电图电极和深度电极相结合的方法对单个单元活动的运动区和运动前区以及后顶叶皮层进行检测。知识价值。提出的研究是一种系统的方法来解决与感知和控制的整合，神经编码/解码以及神经表征与智能行为之间的因果关系相关的基本问题。广泛的影响。提出的实验是具有挑战性的，因此，这些研究的结果可能是突破性的。这项研究是PI？我们的长期目标是推动对自然和复杂行为的理解，这是目前实验和计算神经科学的重要一步。这项研究的基础发现可以为纳米电路的设计提供重要的见解，纳米电路可以替代或治疗知觉运动障碍患者的神经回路缺陷。研究生、本科生和高中生，其中许多是女性，已经并将继续参与这项研究。