Collaborative Research: Model-Based and Model-Free Dimension Reduction with Applications to Bioinformatics

合作研究：基于模型和无模型的降维及其在生物信息学中的应用

• 批准号: 0704621
• 负责人: Bing Li
• 金额: $ 26万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0704621&HistoricalAwards=false
• 关键词: Collaborative; Research; Model; Based; Free

This proposal is focused on sufficient dimension reduction (SDR), which comprises methods for reducing the dimension of the predictor vector X in reference to the response Y in regression or classification problems. In the last 10 to15 years a variety of SDR methods have been developed that do not require a regression modeland that exploit the conditional moments of X given Y. These methods have accrued a striking record of successful applications and have led to a variety of techniques. The investigators propose to introduce inverse reductive models that describe the stochastic structure of X given Y, and not Y given X as in traditionalregression. Preliminary results indicate that this will lead to significant advances in theory, methods and applications. Reductive models provides a unified perspective linking traditional methods such as principal components and various recent model-free inverse methods. In addition, reductive models can provide information bounds, which make it possible to evaluate and improve upon the performance of existing model-free methods in recognizable contexts.High-throughput technologies produce massive amounts of complex and interconnected data. More than ever before, understanding experimental evidence and exploring scientific hypotheses require methods to meaningfully reduce high-dimensional data. This is particularly the case for contemporary genomic sciences. Sequencing techniques, alignment algorithms, microarrays and other emerging experimental technologies generate information on genomes, myriads of novel functional elements within them, patterns of simultaneous expression for the thousands of genes they contain, and patterns of evolution across related species. The need to handle this growing body of information has spun a whole new discipline, Bioinformatics,at the very heart of which are indeed data reduction methods. In this proposal the investigators plan to study a class of inverse reductive models that unify and improve on existing dimension reduction methods, and that are capable of handling situations where the number of variables far exceed the number of subjects. Suchsituations are typical for genomic applications, and are difficult or impossible to study using existing methods.

这一建议的重点是充分降维(SDR)，它包括参照回归或分类问题中的响应Y来降低预测向量X的维度的方法。在过去的10到15年里，各种SDR方法被开发出来，它们不需要回归模型，并且利用给定Y的X的条件矩。这些方法已经积累了惊人的成功应用记录，并导致了各种技术。研究人员建议引入逆约化模型，描述在给定Y的情况下X的随机结构，而不是像传统回归中那样在给定X的情况下描述Y的随机结构。初步结果表明，这将在理论、方法和应用方面取得重大进展。约化模型提供了一个统一的视角，将主成分等传统方法与各种最新的无模型逆方法联系起来。此外，简化模型可以提供信息边界，这使得评估和改进现有无模型方法在可识别环境下的性能成为可能。高通量技术产生大量复杂和相互关联的数据。理解实验证据和探索科学假说比以往任何时候都更需要有意义地减少高维数据的方法。对于当代基因组科学来说，情况尤其如此。测序技术、比对算法、微阵列和其他新兴的实验技术产生关于基因组的信息，其中包含无数新的功能元件，它们包含的数千个基因同时表达的模式，以及相关物种的进化模式。处理这些不断增长的信息量的需求催生了一门全新的学科--生物信息学，其核心确实是数据简化方法。在这项提议中，研究人员计划研究一类逆约简模型，这些模型统一并改进了现有的降维方法，并且能够处理变量数量远远超过对象数量的情况。这种情况是基因组应用的典型情况，很难或不可能用现有的方法进行研究。