NER: Nanofabrication of Field-Effect Fluidic Channels for Dynamic Modulation and Multiplexation of High Speed Microfluidic Biosensors

eccs - 0708540 j吗。优点：本研究的目的是确定电场效应聚合物刷修饰微流控通道阻抗动态调制的可行性。该方法是在微流体通道表面纳米制造场或化学响应聚合物刷，研究聚合物刷修饰微通道的电场效应I/V特性，并开发用于高速生物传感器的动态调制/多路复用技术。动态信道调制和信号复用的使用使得从大量信道中获取数据成为可能，而无需为每个信道单独检测电子设备。这对高速生物测定尤为重要。这项工作的成功交付将导致用于微/纳米尺度生物颗粒快速生物测定的高通量微库尔特计数设备的出现。它还将促进需要在智能纳米通道中控制流量的有源纳米装置的发展，例如用于受控药物输送的分子注射器。更广泛的影响：这个项目的概念、活动和结果将被纳入本科和研究生课程。为机械工程和化学专业的本科生提供生物传感器高级设计项目。该项目将招募本科生研究人员进行研究，重点是代表性不足的少数民族和妇女。通过由美国国家科学基金会教育拨款资助的夏季和周六讲习班，中学生，包括有特殊学习障碍的学生和他们的老师将接触到该项目开发的尖端纳米技术和生物传感器。鼓励中学生探索科学和工程作为未来的职业选择。

ECCS-0708540J. Zhe, University of AkronIntellectual Merits: The objective of this research is to determine the feasibility of dynamic modulation of the impedance of a microfluidic channel modified by electrical-field-effect polymer brushes. The approach is to nanofabricate field or chemical responsive polymer brushes onto the surface of microfluidic channels, investigate the electrical-field-effect I/V characteristics of the polymer brush-modified microchannels and develop dynamic modulation/multiplexing techniques for high speed biosensor applications. The use of dynamic channel modulation and signal multiplexing makes it possible to acquire data from a large number of channels without individual detection electronics for each channel. It is particularly important for high speed bioassays. Successful delivery of the proposed work will lead to high-throughput micro-Coulter counting devices for rapid bioassay of micro/nano scale bioparticles. It will also facilitate the development of active nano devices that require flow control in smart nanochannels, such as molecular syringes for controlled drug delivery. Broader Impacts: The concept, activities, and results from this project will be incorporated into undergraduate and graduate courses. Biosensor senior design projects for undergraduate students in mechanical engineering and chemistry will be offered. Undergraduate researchers will be recruited to conduct research in this project, with an emphasis on underrepresented minorities and women. Through the summer and Saturday workshops funded by an NSF education grant, middle school students, including those with special learning disabilities and their teachers will be exposed to the cutting edge nanotechnology and biosensors developed in this project. The middle school students will be encouraged to explore science and engineering as a future career choice.