IDBR: Development of A Multiplexed Microfluidic Coulter Counting Instrument

IDBR：多重微流控库尔特计数仪的开发

• 批准号: 0649798
• 负责人: Jiang Zhe
• 金额: $ 57.41万
• 依托单位: University of Akron
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0649798&HistoricalAwards=false
• 关键词: IDBR; Development; Multiplexed; Microfluidic; Coulter

This award is for the development of a miniaturized high-throughput Coulter counting instrument for bioassays of cells, biomolecules and bio-particles such as pollen grains. The samples will pass through multiple fluid channels of adjustable size to be measured simultaneously with a single pair of electrodes. The use of dynamic channel modulation and signal multiplexing will make it possible to acquire data from a large number of channels without individual detection electronics for each channel. In addition to the scientific benefits of the instrument, this award will involve students in state-of-the-art microfluidic biosensors. The concept, activities, and results from this research will be incorporated into undergraduate and graduate courses as real-world examples. Students will be recruited also through the university's Undergraduate Research Program, Increasing Diversity in Engineering Academics program and Women in Engineering Program. Middle school students, including those with special learning disabilities, and their teachers will have hands-on experiences with cutting edge BioMEMS technology through summer and Saturday workshops funded by an NSF education grant. A network-based course, ?MEMS: basics & practice?, will be broadcast to the extended community through the university's Distance Learning Network. The state has lost a considerable number of manufacturing jobs to overseas manufacturers in recent years, and the investigators anticipate that this project will help to cultivate a high-tech atmosphere in the region.

该奖项是为了开发一种小型化高通量库尔特计数仪器，用于细胞，生物分子和生物颗粒（如花粉粒）的生物测定。样品将通过多个尺寸可调的流体通道，以便用一对电极同时测量。动态通道调制和信号多路复用的使用将使得有可能从大量通道获取数据，而无需针对每个通道的单独检测电子器件。除了该仪器的科学效益外，该奖项还将让学生参与最先进的微流体生物传感器。这项研究的概念，活动和结果将被纳入本科和研究生课程作为现实世界的例子。学生也将通过大学的本科研究计划，增加工程学术计划和妇女在工程计划的多样性招募。中学生，包括那些有特殊学习障碍的学生，以及他们的老师将通过由NSF教育补助金资助的夏季和周六研讨会，亲身体验尖端的BioMEMS技术。网络课程，？MEMS：基础实践？将通过大学的远程学习网络向广大社区广播。近年来，该州已经失去了相当数量的制造业工作岗位，流向了海外制造商，调查人员预计，该项目将有助于在该地区培养高科技氛围。