Basophils as modulators of humoral and cellular allo-immune responses

嗜碱性粒细胞作为体液和细胞同种免疫反应的调节剂

• 批准号: 181827237
• 负责人: Professor Dr. Matthias Mack
• 金额: --
• 依托单位: Klinik und Poliklinik für Innere Medizin II
• 依托单位国家: 德国
• 项目类别: Clinical Research Units
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/181827237?language=en
• 关键词: Basophils; modulators; humoral; cellular; allo

We have shown that during memory immune responses basophils are able to bind significant amounts of intact antigens on their surface. This binding is mediated by antigen-specific IgE molecules and high affinity IgE receptors on basophils. After re-exposure to antigens basophils become activated and constitute the main source of IL-4 and IL-6 in the spleen and bone marrow. Activated basophils markedly alter the phenotype of CD4+ T cells and play an important role in the development of memory immune responses as shown in models of immunization and infection. A memory type immune response predominates in transplantation, especially after acute rejections or in the setting of chronic transplant rejection. We hypothesize that basophils play an important role as modulators of humoral and cellular immune responses during acute and chronic transplant rejection and that activation of basophils is a good indicator for ongoing memory immune responses. These aspects will be investigated in vitro using MLR reactions, in mouse models of transplantation, and in patients after transplantation.

我们已经证明，在记忆免疫反应期间，嗜碱性粒细胞能够在其表面结合大量完整抗原。这种结合是由抗原特异性 IgE 分子和嗜碱性粒细胞上的高亲和力 IgE 受体介导的。再次接触抗原后，嗜碱性粒细胞被激活，成为脾脏和骨髓中 IL-4 和 IL-6 的主要来源。活化的嗜碱性粒细胞显着改变 CD4+ T 细胞的表型，并在记忆免疫反应的发展中发挥重要作用，如免疫和感染模型所示。记忆型免疫反应在移植中占主导地位，特别是在急性排斥反应后或在慢性移植排斥反应的情况下。我们假设嗜碱性粒细胞在急性和慢性移植排斥过程中作为体液和细胞免疫反应的调节剂发挥着重要作用，并且嗜碱性粒细胞的激活是持续记忆免疫反应的良好指标。这些方面将在体外使用 MLR 反应、移植小鼠模型以及移植后的患者中进行研究。

项目成果

Basophils control T-cell responses and limit disease activity in experimental murine colitis

• DOI: 10.1038/mi.2013.38
• 发表时间: 2014-01-01
• 期刊: MUCOSAL IMMUNOLOGY
• 影响因子: 8
• 作者: Gomez, M. Rodriguez;Talke, Y.;Mack, M.
• 通讯作者: Mack, M.

Effects of Reduced Kidney Function Because of Living Kidney Donation on Left Ventricular Mass

• DOI: 10.1161/hypertensionaha.116.08175
• 发表时间: 2017-02-01
• 期刊: HYPERTENSION
• 影响因子: 8.3
• 作者: Altmann, Ursula;Boeger, Carsten A.;Buchner, Stefan
• 通讯作者: Buchner, Stefan

Basophils Support the Survival of Plasma Cells in Mice

• DOI: 10.4049/jimmunol.1002319
• 发表时间: 2010-12-15
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Gomez, Manuel Rodriguez;Talke, Yvonne;Mack, Matthias
• 通讯作者: Mack, Matthias