NER: Exploration of DNA-Based Nanoscale Building Block (DNAnBLOCK) for Controllable and Scalable Fabrication of Active Nanostructures

NER：探索基于 DNA 的纳米级构建模块 (DNAnBLOCK)，以实现活性纳米结构的可控和可扩展制造

• 批准号: 0709121
• 负责人: Jin-Woo Kim
• 金额: --
• 依托单位: University of Arkansas
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0709121&HistoricalAwards=false
• 关键词: NER; Exploration; DNA; Based; Nanoscale

In order to achieve the functionality, reliability, and scalability of current microfabrication, DNA-based self-assembly should increase complexity of the nanostructures that it can construct, and control over nanocomponent placement. The key problem behind this significant hurdle is the lack of control over fundamental building blocks for self-assembly. This research explores DNA-based nanoscale building blocks (DNAnBLOCKs) to construct more complicated and controlled nanostructures through DNA-directed self-assembly. The DNAnBLOCK is a DNA-based nanostructure, in which strand sequence, location, and orientation are precisely controlled, enabling the 'controlled' functionality and directionality. With the well-defined functionality and directionality, self-assembly can lead to precisely controlled structures with greater complexity. In addition, DNA oligonucleotides used are non-crosshybridizing (NCH), and unplanned defects and errors are minimized. Furthermore, the DNAnBLOCK is capable of three-dimensional growth and is highly scalable. Thus, this research addresses the urgent need in nanotechnology to realize nanoscale materials and devices that have practical use and more capability than existing technologies. This research will benefit the society in several areas. Information gained from the research would benefit molecular electronic industries by making nanotechnology more practical and more functional. It would also be a useful resource to the researchers in other applications in biology, medicine, and sensors. Students will be educated through involvement in this research.

为了实现当前微制造的功能性、可靠性和可扩展性，基于DNA的自组装应该增加它可以构建的纳米结构的复杂性，并控制纳米组件的放置。这一重大障碍背后的关键问题是缺乏对自组装基本构件的控制。本研究探索了基于DNA的纳米级构建块（DNAnBLOCKs），通过DNA指导的自组装来构建更复杂和可控的纳米结构。DNAnBLOCK是一种基于DNA的纳米结构，其中链序列，位置和方向都得到精确控制，从而实现“受控”功能和方向性。有了明确的功能和方向性，自组装可以导致更复杂的精确控制结构。此外，使用的DNA寡核苷酸是非交叉杂交（NCH）的，并且计划外的缺陷和错误被最小化。此外，DNAnBLOCK能够三维生长，并且具有高度可扩展性。因此，这项研究解决了纳米技术的迫切需要，以实现具有实际用途和比现有技术更多的能力的纳米材料和器件。这项研究将在多个领域造福社会。从这项研究中获得的信息将使纳米技术更加实用和实用，从而使分子电子工业受益。这也将是一个有用的资源，研究人员在生物学，医学和传感器的其他应用。学生将通过参与这项研究受到教育。