One and two-dimensional superheated water chromatographies

佛罗里达州立大学的John Dorsey教授和他的团队正在研究将过热水作为色谱流动相和反应介质。他们深入研究了过热水色谱中保留的热力学和salvatochromic，旨在阐明保留机制，提高对该技术的可预测性和理解。由于色谱是一种广泛使用的分离技术，并且由于色谱实验经常被用作各种分配过程的模型，因此这种理解是非常可取的。过热水色谱的使用目前仅限于学术实验室；在分析实验室接受该技术之前，有必要对其进行更好的基础理解。使用过热水作为流动相有许多优点，例如降低成本、提高分析速度和改进分析物检测。这些优势对于推进“绿色”化学的目标，以及制药工业最近对过程分析技术（PAT）的推动尤其重要。在这里学到的信息也会影响这种溶剂作为反应介质的使用。与该计划相关的学生将获得对重要多学科领域的宝贵见解。

Professor John Dorsey and his group at Florida State University are studying superheated water as a chromatographic mobile phase and reaction medium. Thorough thermodynamic and salvatochromic investigation of retention in superheated water chromatography, they aim to elucidate the retention mechanism and improve predictability and understanding of the technique. Because chromatography is such a widely used separation technique, and because the chromatography experiment is often used as a model for a variety of partitioning processes, such an understanding is highly desirable. Use of superheated water chromatography is currently limited to the academic laboratory; better fundamental understanding is necessary before the technique can be accepted in the analytical laboratory. There are a variety of advantages that are associated with using superheated water as a mobile phase, such as a reduction in cost, increase in analysis speed, and improvements in analyte detection. These advantages could be especially important for furthering the goals of "green" chemistry, and for the recent drive for Process Analytical Technology (PAT) by the pharmaceutical industry. Information learned here will also impact the use of this solvent as a reaction medium. Students associated with this program gain valuable insight into important multidisciplinary areas.