Photochemical synthesis of glycopeptides and peptide thioesters

糖肽和肽硫酯的光化学合成

• 批准号: 0719538
• 负责人: Katja Michael
• 金额: $ 32.5万
• 依托单位: University of Texas at El Paso
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0719538&HistoricalAwards=false
• 关键词: Photochemical; synthesis; glycopeptides; peptide; thioesters

Glycoproteins play important roles in biology, and are needed for the study of biological processes. Since it is difficult to isolate pure glycoproteins from biomaterials, an alternative approach is to generate these compounds by chemical synthesis. This requires the synthesis of (glyco)peptide thioesters and (glyco)peptides, which are used as building blocks. The P.I.'s research focuses on the development of a unique photochemical method, which can be used to synthesize the desired components under mild reaction conditions. The building blocks are then reacted with each other, which will produce large glycopeptides.The proposed research will be conducted by students at the University of Texas at El Paso, a recognized Hispanic Serving Institution. The students will obtain expertise in modern carbohydrate and peptide chemistry. Some of the research will be done in collaboration with an outstanding Japanese group, which will contribute to a competitive and invigorating learning environment for the P.I.'s students. Due to the cross-disciplinary nature of the project, the anticipated results will have an impact on the science community well beyond organic chemistry.

糖蛋白在生物学中起着重要的作用，是研究生物过程所必需的。 由于很难从生物材料中分离出纯的糖蛋白，另一种方法是通过化学合成来产生这些化合物。 这需要合成用作结构单元的（糖）肽硫酯和（糖）肽。 私家侦探的研究重点是开发一种独特的光化学方法，该方法可用于在温和的反应条件下合成所需的组分。 然后，这些结构单元相互反应，产生大的糖肽。这项拟议中的研究将由德克萨斯大学埃尔帕索分校的学生进行，这是一个公认的西班牙裔服务机构。 学生将获得现代碳水化合物和肽化学的专业知识。 一些研究将与一个优秀的日本小组合作完成，这将有助于为PI提供一个充满竞争力和活力的学习环境。的学生。 由于该项目的跨学科性质，预期结果将对科学界产生远远超出有机化学的影响。