MRI: Development of a Pulsed High Frequency Quasioptical Electron Spin Resonance Spectrometer

这是一项为生物技术和纳米材料的研究、教育和培训开发脉冲高场准光学电子自旋共振(ESR)光谱仪的奖项。五个教职人员将使用该仪器在以下几个领域开展研究：高场自旋标记对蛋白质的静电作图；自旋电子器件新材料的表征；纳米复合燃料电池和催化膜中界面相互作用的测量；基于蛋白质的纳米器件的表征。脉冲方法的扩展将提供重要的能力，将导致在生物技术和材料科学中的新应用。这些包括(1)使用双电子-电子共振(DER)光谱详细地表征分子尺度上的自旋-自旋距离和距离分布，(2)使用线性电场效应(LEFE)测量引入蛋白质或纳米结构的标记处的微观局部电场的能力，(3)通过自旋弛豫测量大分子和纳米结构中详细的动力学行为的高分辨率。该仪器将作为该大学现有的连续波高场ESR设施的延续而运行。该奖项将为快速增长的高场ESR研究领域实施一项培训计划。将为学生提供实习机会，以增加他们在新的高场ESR方法方面的培训广度。该大学有一个合作教育项目，合格的本科生将在ESR设施完成他们的合作学期。该大学有许多针对代表不足的群体的外展项目，包括市中心地区的学生。

This is an award for developing a pulsed high-field quasioptical Electron Spin Resonance (ESR) spectrometer for research, education, and training in biotechnology and nanomaterials. Five faculty will use the instrument to carry out research in several areas as follows: Electrostatic mapping of proteins by high-field spin labeling; Characterization of novel materials for spintronic devices; Measurements of interfacial interactions in nanocomposite fuel cell and catalytic membranes; Characterization of protein-based nanodevices. The extension to pulsed methodology will provide important capabilities that will lead to new applications in biotechnology and materials science. These include (1) detailed characterization of spin-spin distances and distance distributions on the molecular scale using double electron-electron resonance (DEER) spectroscopy, (2) the ability to measure the microscopic local electric field at a label introduced into a protein or nanostructure using the linear electric field effect (LEFE), (3) high resolution of detailed dynamic behavior in macromolecules and nanostructures via spin relaxation measurements. The instrument will be operated as a continuation of the existing continuous-wave high-field ESR facility at the university. This award will implement a training program for the rapidly growing research area of high-field ESR. Internships will be available for students to increase the breadth of their training in new high-field ESR methods. The university has a co-op education program, and qualified undergrads will do their co-op semester in the ESR facility. The university has many outreach programs for underrepresented groups, including students in the inner city area.