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Novel Methods for High Resolution NMR Spectroscopy in Inhomogeneous Fields

非均匀场高分辨率核磁共振波谱的新方法

基本信息

批准号：
0724057
负责人：
Navin Khaneja
金额：
$ 42万
依托单位：
Harvard University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2007
资助国家：
美国
起止时间：
2007-11-15 至 2011-10-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0724057&HistoricalAwards=false
关键词：
Novel Methods Resolution NMR Spectroscopy

项目摘要

Professor Navin Khaneja and his group at Harvard University are supported by the Analytical and Surface Chemistry Program in the Division of Chemistry for a collaboration with Professor Steffen Glaser at the Technical University of Munich to develop novel methods for high resolution nuclear magnetic resonance (NMR) spectroscopy in inhomogeneous static and radio-frequency fields. The work employs novel radio-frequency pulse sequences and gradient waveform designs to enable high resolution NMR in mobile and ex-situ NMR applications in materials science, chemical engineering, and geosciences. Systematic use of methods of control theory can generate pulse sequence designs that are significantly shorter than those accessible by conventional methods but offer comparable compensation performance. These optimal designs help to minimize relaxation losses that are always present and thereby improve the sensitivity. This international collaboration (with the German portion supported by the German Science Foundation - DFG) provides students and postdocs with exceptional opportunities to pair theoretical and experimental concepts of NMR, plus broad experience in international collaboration. The methods developed in this work are expected to be broadly applicable to other coherent spectroscopies and areas of quantum information science and coherent control.

哈佛大学的Navin Khaneja教授和他的团队得到了化学系分析和表面化学项目的支持，与慕尼黑工业大学的Steffen Glaser教授合作，开发了在不均匀静态和射频场中进行高分辨率核磁共振（NMR）光谱分析的新方法。这项工作采用了新的射频脉冲序列和梯度波形设计，使高分辨率NMR在移动的和非原位NMR应用在材料科学，化学工程和地球科学。系统地使用控制理论的方法可以产生比传统方法可获得的脉冲序列设计短得多的脉冲序列设计，但提供相当的补偿性能。这些优化设计有助于最大限度地减少始终存在的弛豫损耗，从而提高灵敏度。这种国际合作（德国部分由德国科学基金会- DFG支持）为学生和博士后提供了将NMR的理论和实验概念配对的绝佳机会，以及在国际合作方面的广泛经验。在这项工作中开发的方法预计将广泛适用于其他相干光谱和量子信息科学和相干控制领域。