Functional analysis of the histone arginine methyltransferase PRMT6 (A03)

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The Protein arginine methyltransferase 6 (PRMT6) catalyzes asymmetric dimethylation of histone H3 at arginine 2 (H3R2me2a), which contributes to opposing transcriptional effects depending on its genomic location, activation at enhancers and repression at promoters. In the next funding period we will characterize the cross-talk of H3R2me2a with enhancer marks, the binding sites and recruitment mechanisms of PRMT6 to chromatin, its target site-specific chromatin interactors and finally the in vivo function of PRMT6/H3R2me2a in neurogenesis.