Development of an interdisciplinary program in transforming computational science and engineering tools for cancer research
开发跨学科项目,转变癌症研究的计算科学和工程工具
基本信息
- 批准号:0729091
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-10-01 至 2011-09-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
0729091DongThe main objective of this proposal is to apply emerging technologies in developing multi-scale computational approaches for studying heterotypic cell-cell collision and adhesion to a substrate under dynamic shear forces. In particular, the focus is on leukocyte (PMN)-melanoma cell emboli formation in a non-linear shear flow and subsequent tethering to the vascular endothelium (EC) as a result of cell-cell aggregation. The extent of tumor cell adhesion to a vessel wall is governed by the kinetic formation/disruption of receptor ligand bonds, the hydrodynamic shear and the heterotypic cell populations within the circulation. The project will provide understanding for the complex role of micro-hemodynamics, heterotypic cell populations, secreted chemokines, and PMN-melanoma adhesion in the recruitment of metastatic cancer cells to the EC in the microcirculation. A multi-scale computational fluid dynamics (CFD) code will be applied to perform direct numerical simulation, where each cell in the system is explicitly resolved. This research will promote new crossdisciplinary approaches in research and education, integrating biomedical engineering, physical sciences and life sciences. The research results will be actively disseminated, using timely publications in the research literature as well as through the investigator's web sites and seminar lectures. The investigators will foster education through the application of engineering principles to cell biology, integrated with applied mathematics, mechanics, computational science, bioengineering and medical sciences.
本文的主要目的是应用新兴技术开发多尺度计算方法来研究异型细胞-细胞碰撞和在动态剪切力作用下与基底的粘附。特别地,重点是白细胞(PMN)-黑色素瘤细胞在非线性剪切流中的栓塞形成,以及随后作为细胞-细胞聚集的结果捆绑到血管内皮(EC)。肿瘤细胞粘附血管壁的程度受受体配体键的动力学形成/破坏、流体动力学剪切和循环内的异型细胞群的影响。该项目将为微循环中转移性癌细胞向EC募集过程中微循环中微血流动力学、异型细胞群、分泌趋化因子和pmn -黑色素瘤粘附的复杂作用提供理解。将应用多尺度计算流体动力学(CFD)代码进行直接数值模拟,其中系统中的每个单元都被显式解析。这项研究将促进新的跨学科研究和教育方法,整合生物医学工程,物理科学和生命科学。将利用研究文献中的及时出版物以及通过研究者的网站和研讨会讲座积极传播研究结果。研究人员将通过将工程原理应用于细胞生物学,并结合应用数学、力学、计算科学、生物工程和医学科学来促进教育。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Cheng Dong其他文献
Deriving heterogeneous experts weights from incomplete linguistic preference relations based on uninorm consistency
基于一致一致性的不完全语言偏好关系推导异质专家权重
- DOI:
10.1016/j.knosys.2018.03.013 - 发表时间:
2018-06 - 期刊:
- 影响因子:8.8
- 作者:
Cheng Dong;Zhou Zhili;Cheng Faxin;Wang Juan - 通讯作者:
Wang Juan
Polymer-based composites for electromagnetic interference shielding: principles, fabrication, and applications
用于电磁干扰屏蔽的聚合物基复合材料:原理、制备及应用
- DOI:
10.1016/j.compositesa.2025.108927 - 发表时间:
2025-07-01 - 期刊:
- 影响因子:8.900
- 作者:
De Li;Cheng Dong;Ai Ping Zhang;Hai Lan Lin;Bi You Peng;Ke Yang Ni;Ke Cheng Yang;Jun Bian;Dai Qiang Chen - 通讯作者:
Dai Qiang Chen
Multi-Scale study on combustion acceleration and Self-Catalytic mechanisms of Nickel-Based energetic complex [Ni(Nsub2/subHsub4/sub)sub2/sub](Nsub3/sub)sub2/sub
镍基含能配合物[Ni(N₂H₄)₂](N₃)₂燃烧加速及自催化机制的多尺度研究
- DOI:
10.1016/j.fuel.2025.135134 - 发表时间:
2025-09-01 - 期刊:
- 影响因子:7.500
- 作者:
Cheng Dong;Shiyong Chen;Lixiao Shen;Tu Xu;Yinning Zeng;Yan Li;Zhenxin Yi;Chenguang Zhu;Lin Zhang;Shunguan Zhu - 通讯作者:
Shunguan Zhu
Charge Density Wave and Crystal Structure of $$\hbox {K}_{x}\hbox {WO}_{3}$$ ( $$x=0.20$$ and 0.22) Prepared by Hybrid Microwave Method
- DOI:
10.1007/s10909-017-1762-6 - 发表时间:
2017-02-24 - 期刊:
- 影响因子:1.400
- 作者:
Runze Chen;Chaojun Gao;Kun Bu;Xiaoyu Hao;Zichen Wang;Lianjun Wen;Juan Guo;Mingju Chao;Erjun Liang;Lihong Yang;Cheng Dong - 通讯作者:
Cheng Dong
A least squares based diamond scheme for 3D heterogeneous and anisotropic diffusion problems on polyhedral meshes
基于最小二乘的菱形方案,用于解决多面体网格上的 3D 异质和各向异性扩散问题
- DOI:
10.1016/j.amc.2021.126847 - 发表时间:
2022-04 - 期刊:
- 影响因子:4
- 作者:
Cheng Dong;Tong Kang - 通讯作者:
Tong Kang
Cheng Dong的其他文献
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{{ truncateString('Cheng Dong', 18)}}的其他基金
EAGER: Dynamic Affinity for Regulation of Cell Signaling
EAGER:细胞信号传导调节的动态亲和力
- 批准号:
1330663 - 财政年份:2013
- 资助金额:
-- - 项目类别:
Standard Grant
NIH-NSF BBSI: The Penn State Summer Institute (PSSI) for Biomaterials and Bio-nanotechnology
NIH-NSF BBSI:宾夕法尼亚州立大学生物材料和生物纳米技术夏季研究所 (PSSI)
- 批准号:
0234026 - 财政年份:2002
- 资助金额:
-- - 项目类别:
Continuing Grant
Molecular Dynamics in Tumor Cell Extravasation
肿瘤细胞外渗的分子动力学
- 批准号:
0138474 - 财政年份:2002
- 资助金额:
-- - 项目类别:
Continuing Grant
International Travel Grant: The First Korea-U.S. Joint Seminar on Biomedical Engineering
国际旅行补助金:首个韩美补助金
- 批准号:
9812245 - 财政年份:1998
- 资助金额:
-- - 项目类别:
Standard Grant
CAREER: Faculty Early Career Development in Education and Research
职业:教师教育和研究领域的早期职业发展
- 批准号:
9502069 - 财政年份:1995
- 资助金额:
-- - 项目类别:
Continuing Grant
Micromechanics of Cell Activation in Cancer Metastasis
癌症转移中细胞激活的微观力学
- 批准号:
9308809 - 财政年份:1993
- 资助金额:
-- - 项目类别:
Standard Grant
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职业:文化、背景和发展政策:跨学科研究和培训项目
- 批准号:
2238314 - 财政年份:2023
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Planning Study for the Development of Sigma 2 ligands as Analgesics
Sigma 2 配体镇痛药开发规划研究
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10641500 - 财政年份:2023
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A pilot feasibility study of digitally delivered modules focused on preventing the development of obesity during the first year of life within an existing statewide home visitation program
对数字交付模块进行试点可行性研究,重点是在现有的全州家访计划中预防生命第一年发生肥胖
- 批准号:
10667696 - 财政年份:2023
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Development of personalized healthy food incentives to improve diet and cardiovascular risk
制定个性化健康食品激励措施以改善饮食和心血管风险
- 批准号:
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An Immersive, Interdisciplinary Training Program for Workforce Development and Sustained Engagement in Entrepreneurship and Translational Research for Alzheimer's Disease and Related Disorders
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