Micromechanics of Cell Activation in Cancer Metastasis

癌症转移中细胞激活的微观力学

• 批准号: 9308809
• 负责人: Cheng Dong
• 金额: $ 11万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-01 至 1997-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9308809&HistoricalAwards=false
• 关键词: Micromechanics; Cell; Activation; Cancer; Metastasis

This Research Initiation grant will allow the investigator to study tumor cell micromotion during chemotactic stimulation through both experimental observations and mathematical modeling. The specific aims are to: 1) develop a system to manipulate tumor cells during pseudopod migration, 2) determine the factors affecting pseudopod protrusion; 3) develop mathematical models for pseudopod formation and cell movement; and 4) correlate pseudopod characteristics with cytoskeletal structure. This research is important since it will contribute towards and understanding of the mechanics of metastases of tumor cells and provide basic information needed to understand physiological processes such as tissue development.

这项研究启动补助金将允许研究者 趋化刺激过程中肿瘤细胞微运动研究 通过实验观察和数学建模。 具体目标是：1）开发一个系统， 伪足迁移过程中的肿瘤细胞，2）确定因素 影响伪足突出; 3）建立数学模型 用于伪足形成和细胞运动;以及4）与 具有细胞骨架结构的伪足特征。 这项研究很重要，因为它将有助于 了解肿瘤细胞转移的机制， 提供了解生理所需的基本信息 例如组织发育。