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Molecular Dynamics in Tumor Cell Extravasation

Molecular Dynamics in Tumor Cell Extravasation
肿瘤细胞外渗的分子动力学
批准号:
0138474
负责人:
Cheng Dong
金额:
$29.7万
依托单位国家:
美国
项目类别:
Continuing Grant
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-07-01 至 2006-06-30

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中文摘要
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英文摘要
0138474DongUnder this Investigator Initiated Award, the PI will focus on assessing the effect that human neutrophil/leukocyte (PMN) adhesion to melanoma cells has on melanoma cell adhesion and transmigration across endothelium, i.e., tumor cell extravasation. Evidence suggests that leukocytes assist tumor cell adhesion and transmigration. Studies will be performed in a novel flow chamber that permits examination of the effect of flow on tumor cell attachment. The four aims are: 1) to characterize the role of tumor-elicited leukocytes in dynamic tumor cell extravasation, 2) to identify tumor-secreted chemokines associated with PMN recruitment and determine their ability to assist with tumor extravasation under flow conditions, 3) to determine hydrodynamic shear effect on adhesion efficiency in tumor-leukocyte interaction and 4) to foster education/teaching through the application of engineering principles to cell biology.
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会议论文
EAGER: Dynamic Affinity for Regulation of Cell Signaling
Development of an interdisciplinary program in transforming computational science and engineering tools for cancer research
NIH-NSF BBSI: The Penn State Summer Institute (PSSI) for Biomaterials and Bio-nanotechnology
International Travel Grant: The First Korea-U.S. Joint Seminar on Biomedical Engineering
国内基金
海外基金
β-arrestin2- MFN2-Mitochondrial Dynamics轴调控星形胶质细胞功能对抑郁症进程的影响及机制研究
  • 批准号:
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    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2023
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