Molecular Dynamics in Tumor Cell Extravasation
肿瘤细胞外渗的分子动力学
基本信息
- 批准号:0138474
- 负责人:
- 金额:$ 29.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-07-01 至 2006-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
0138474DongUnder this Investigator Initiated Award, the PI will focus on assessing the effect that human neutrophil/leukocyte (PMN) adhesion to melanoma cells has on melanoma cell adhesion and transmigration across endothelium, i.e., tumor cell extravasation. Evidence suggests that leukocytes assist tumor cell adhesion and transmigration. Studies will be performed in a novel flow chamber that permits examination of the effect of flow on tumor cell attachment. The four aims are: 1) to characterize the role of tumor-elicited leukocytes in dynamic tumor cell extravasation, 2) to identify tumor-secreted chemokines associated with PMN recruitment and determine their ability to assist with tumor extravasation under flow conditions, 3) to determine hydrodynamic shear effect on adhesion efficiency in tumor-leukocyte interaction and 4) to foster education/teaching through the application of engineering principles to cell biology.
0138474根据这项由研究者发起的奖项,PI将专注于评估人中性粒细胞/白细胞(PMN)与黑色素瘤细胞的黏附对黑色素瘤细胞黏附和跨内皮细胞迁移(即肿瘤细胞外渗)的影响。有证据表明,白细胞有助于肿瘤细胞的黏附和迁移。研究将在一种新的流动室中进行,该流动室允许检查流动对肿瘤细胞附着的影响。这四个目标是:1)表征肿瘤诱导的白细胞在肿瘤细胞动态渗出中的作用;2)鉴定与PMN募集相关的肿瘤分泌的趋化因子,并确定它们在流动条件下协助肿瘤渗出的能力;3)确定流体动力剪切对肿瘤-白细胞相互作用中黏附效率的影响;4)通过将工程学原理应用于细胞生物学来促进教育/教学。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Cheng Dong其他文献
Deriving heterogeneous experts weights from incomplete linguistic preference relations based on uninorm consistency
基于一致一致性的不完全语言偏好关系推导异质专家权重
- DOI:
10.1016/j.knosys.2018.03.013 - 发表时间:
2018-06 - 期刊:
- 影响因子:8.8
- 作者:
Cheng Dong;Zhou Zhili;Cheng Faxin;Wang Juan - 通讯作者:
Wang Juan
Multi-Scale study on combustion acceleration and Self-Catalytic mechanisms of Nickel-Based energetic complex [Ni(Nsub2/subHsub4/sub)sub2/sub](Nsub3/sub)sub2/sub
镍基含能配合物[Ni(N₂H₄)₂](N₃)₂燃烧加速及自催化机制的多尺度研究
- DOI:
10.1016/j.fuel.2025.135134 - 发表时间:
2025-09-01 - 期刊:
- 影响因子:7.500
- 作者:
Cheng Dong;Shiyong Chen;Lixiao Shen;Tu Xu;Yinning Zeng;Yan Li;Zhenxin Yi;Chenguang Zhu;Lin Zhang;Shunguan Zhu - 通讯作者:
Shunguan Zhu
Polymer-based composites for electromagnetic interference shielding: principles, fabrication, and applications
用于电磁干扰屏蔽的聚合物基复合材料:原理、制备及应用
- DOI:
10.1016/j.compositesa.2025.108927 - 发表时间:
2025-07-01 - 期刊:
- 影响因子:8.900
- 作者:
De Li;Cheng Dong;Ai Ping Zhang;Hai Lan Lin;Bi You Peng;Ke Yang Ni;Ke Cheng Yang;Jun Bian;Dai Qiang Chen - 通讯作者:
Dai Qiang Chen
Charge Density Wave and Crystal Structure of $$\hbox {K}_{x}\hbox {WO}_{3}$$ ( $$x=0.20$$ and 0.22) Prepared by Hybrid Microwave Method
- DOI:
10.1007/s10909-017-1762-6 - 发表时间:
2017-02-24 - 期刊:
- 影响因子:1.400
- 作者:
Runze Chen;Chaojun Gao;Kun Bu;Xiaoyu Hao;Zichen Wang;Lianjun Wen;Juan Guo;Mingju Chao;Erjun Liang;Lihong Yang;Cheng Dong - 通讯作者:
Cheng Dong
A least squares based diamond scheme for 3D heterogeneous and anisotropic diffusion problems on polyhedral meshes
基于最小二乘的菱形方案,用于解决多面体网格上的 3D 异质和各向异性扩散问题
- DOI:
10.1016/j.amc.2021.126847 - 发表时间:
2022-04 - 期刊:
- 影响因子:4
- 作者:
Cheng Dong;Tong Kang - 通讯作者:
Tong Kang
Cheng Dong的其他文献
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{{ truncateString('Cheng Dong', 18)}}的其他基金
EAGER: Dynamic Affinity for Regulation of Cell Signaling
EAGER:细胞信号传导调节的动态亲和力
- 批准号:
1330663 - 财政年份:2013
- 资助金额:
$ 29.7万 - 项目类别:
Standard Grant
Development of an interdisciplinary program in transforming computational science and engineering tools for cancer research
开发跨学科项目,转变癌症研究的计算科学和工程工具
- 批准号:
0729091 - 财政年份:2007
- 资助金额:
$ 29.7万 - 项目类别:
Standard Grant
NIH-NSF BBSI: The Penn State Summer Institute (PSSI) for Biomaterials and Bio-nanotechnology
NIH-NSF BBSI:宾夕法尼亚州立大学生物材料和生物纳米技术夏季研究所 (PSSI)
- 批准号:
0234026 - 财政年份:2002
- 资助金额:
$ 29.7万 - 项目类别:
Continuing Grant
International Travel Grant: The First Korea-U.S. Joint Seminar on Biomedical Engineering
国际旅行补助金:首个韩美补助金
- 批准号:
9812245 - 财政年份:1998
- 资助金额:
$ 29.7万 - 项目类别:
Standard Grant
CAREER: Faculty Early Career Development in Education and Research
职业:教师教育和研究领域的早期职业发展
- 批准号:
9502069 - 财政年份:1995
- 资助金额:
$ 29.7万 - 项目类别:
Continuing Grant
Micromechanics of Cell Activation in Cancer Metastasis
癌症转移中细胞激活的微观力学
- 批准号:
9308809 - 财政年份:1993
- 资助金额:
$ 29.7万 - 项目类别:
Standard Grant
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