EXP-SA: Collaborative Research: Ultratrace Detection of Explosives Enabled by an Integrated Microfluidic Nanosensing System

EXP-SA：合作研究：通过集成微流控纳米传感系统实现爆炸物的超痕量检测

• 批准号: 0730503
• 负责人: Jeff Wang
• 金额: $ 19.69万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0730503&HistoricalAwards=false
• 关键词: EXP; SA; Collaborative; Research; Ultratrace

This collaborative research proposal focuses on developing a miniaturized analytical system, aiming to achieve rapid detection of ultratrace explosives with minimal false alarm rates. In this system, the explosive-absorbed or explosive particles will be collected and processed utilizing droplet-based microfluidic technologies. The explosive targets will then detected using two different immuno-sensors that are developed based on Au and quantum dot nanoparticles respectively. Validation of the proposed system will be carried out using detection of trinitrotoluene (TNT) as a model assay. Intellectual merit The proposed system includes an unprecedented level of high sensitivity, minimal false alarm rates, and near real-time response. This system is automatic and re-usable, allowing continuous sensing with a low level of maintenance. Broader ImpactsThe project has high impact on homeland security and education. The detection system can be deployed as a standoff detection platform with a relatively low cost for monitoring of trace explosives in airports, security buildings and other infrastructures. The miniaturized system can be implemented as a portable system for tracing mobile explosive sources. Besides, high school and undergraduate students will be invited to participate in proposed research and a cross-disciplinary seminar in micro/nanotechnology will be created.

该合作研究计划的重点是开发小型化分析系统，旨在以最小的误报率实现超痕量爆炸物的快速检测。在该系统中，将利用基于液滴的微流体技术收集和处理爆炸物吸收或爆炸性颗粒。然后，将使用分别基于金和量子点纳米颗粒开发的两种不同的免疫传感器来检测爆炸目标。 所提出的系统的验证将使用三硝基甲苯（TNT）的检测作为模型测定来进行。智力优势 所提出的系统具有前所未有的高灵敏度、最低的误报率和近乎实时的响应。该系统是自动的且可重复使用，允许连续传感且维护量低。更广泛的影响该项目对国土安全和教育具有重大影响。该检测系统可以部署为远距离检测平台，成本相对较低，用于监测机场、安全建筑和其他基础设施中的痕量爆炸物。该小型化系统可以实现为用于追踪移动爆炸源的便携式系统。此外，将邀请高中生和本科生参与拟议的研究，并将创建微/纳米技术的跨学科研讨会。