EXP-SA: Collaborative Research: Ultratrace Detection of Explosives Enabled by an Integrated Microfluidic Nanosensing System

EXP-SA：合作研究：通过集成微流控纳米传感系统实现爆炸物的超痕量检测

• 批准号: 0730503
• 负责人: Jeff Wang
• 金额: $ 19.69万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0730503&HistoricalAwards=false
• 关键词: EXP; SA; Collaborative; Research; Ultratrace

This collaborative research proposal focuses on developing a miniaturized analytical system, aiming to achieve rapid detection of ultratrace explosives with minimal false alarm rates. In this system, the explosive-absorbed or explosive particles will be collected and processed utilizing droplet-based microfluidic technologies. The explosive targets will then detected using two different immuno-sensors that are developed based on Au and quantum dot nanoparticles respectively. Validation of the proposed system will be carried out using detection of trinitrotoluene (TNT) as a model assay. Intellectual merit The proposed system includes an unprecedented level of high sensitivity, minimal false alarm rates, and near real-time response. This system is automatic and re-usable, allowing continuous sensing with a low level of maintenance. Broader ImpactsThe project has high impact on homeland security and education. The detection system can be deployed as a standoff detection platform with a relatively low cost for monitoring of trace explosives in airports, security buildings and other infrastructures. The miniaturized system can be implemented as a portable system for tracing mobile explosive sources. Besides, high school and undergraduate students will be invited to participate in proposed research and a cross-disciplinary seminar in micro/nanotechnology will be created.

该协作研究建议着重于开发一个小型分析系统，旨在以最低的错误警报率来快速检测超爆炸物。在此系统中，将利用基于液滴的微流体技术收集并处理爆炸物吸收或爆炸性颗粒。然后，将使用基于AU和量子点纳米颗粒开发的两个不同的免疫传感器来检测爆炸性目标。 拟议系统的验证将使用Trinitrotoluene（TNT）作为模型测定法进行。知识分子优点该系统包括前所未有的高灵敏度，最小的错误警报率以及接近实时响应的水平。该系统是自动且可重复使用的，可以连续感测，维护水平较低。更广泛的影响该项目对国土安全和教育有很大影响。检测系统可以作为僵局检测平台部署，其成本相对较低，用于监视机场，安全建筑物和其他基础设施中的微量爆炸物。小型化系统可以作为追踪移动爆炸物来源的便携式系统实现。此外，将邀请高中和本科生参加拟议的研究，并将创建微/纳米技术的跨学科研讨会。