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Effects of an oral supplementation of arginine, citrulline and glutamine on the development and progression of non-alcoholic fatty liver disease (NAFLD): Role of gender and age

口服补充精氨酸、瓜氨酸和谷氨酰胺对非酒精性脂肪肝 (NAFLD) 发生和进展的影响：性别和年龄的作用

基本信息

批准号：
183849079
负责人：
Professorin Dr. Ina Bergheim
金额：
--
依托单位：
Department für Ernährungswissenschaften
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2010
资助国家：
德国
起止时间：
2009-12-31 至 2019-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/183849079?language=en
关键词：
Effects oral supplementation arginine citrulline

项目摘要

The prevalence of non-alcoholic fatty liver disease (NAFLD) hasmarkedly increased and by now NAFLD is one of the most frequentliver diseases worldwide; however, universally accepted, successfultherapies are still lacking. Studies indicate that even early stages ofNAFLD are associated with an increased intestinal translocation ofbacterial endotoxin in the intestine and an induction of toll-likereceptor (TLR)-dependent signaling pathways in the liver. Results ofthe first funding period using animal models suggest that an oralsupplementation of arginine, citrulline or glutamine possess protectiveeffects on the development of NAFLD. Our data further suggest thatthe mechanisms involved herein markedly differ between the threeamino acids. If an oral supplementation of the amino acids alsopossess therapeutic effects on the progression of NAFLD has not yetbeen clarified. Therefore, the aim of the present research project is (1)to further delineate the mechanisms involved in the protective effectsof arginine, citrulline and glutamine on the development of NAFLD inmice with a special focus on changes in hepatic fatty acid distributionand intestinal microbiota and (2) to determine if the three amino acidsalso possess therapeutic effects on the disease in mice thereby alsoaiming to add to the development of new prevention and therapeuticstrategies.

非酒精性脂肪性肝病（NAFLD）的患病率显著增加，目前NAFLD是世界上最常见的肝脏疾病之一；然而，普遍接受的、成功的治疗方法仍然缺乏。研究表明，即使是早期的nafld也与肠道细菌内毒素的肠道易位增加和肝脏中toll样受体（TLR）依赖性信号通路的诱导有关。第一个资助期动物模型的结果表明，口服补充精氨酸、瓜氨酸或谷氨酰胺对NAFLD的发展具有保护作用。我们的数据进一步表明，这里涉及的机制在三种氨基酸之间显着不同。口服补充氨基酸是否对NAFLD的进展也有治疗作用尚未明确。因此，本研究项目的目的是：(1)进一步阐明精氨酸、瓜氨酸和谷氨酰胺对小鼠NAFLD发展的保护作用机制，特别关注肝脏脂肪酸分布和肠道微生物群的变化；(2)确定这三种氨基酸是否对小鼠NAFLD也具有治疗作用，从而也旨在促进新的预防和治疗策略的发展。