An Intracranial Energy Harvesting Device for Treatment of Neurological Disorders

用于治疗神经系统疾病的颅内能量收集装置

• 批准号: 0753801
• 负责人: Babak Ziaie
• 金额: --
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-10 至 2010-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0753801&HistoricalAwards=false
• 关键词: Intracranial; Energy; Harvesting; Device; Treatment

The objective of this research is to develop an energy scavenging device for use in both medical and non-medical applications. The primary focus will be on intracranial implantable systems for treatment of neurological disorders such as epilepsy. The approach is to convert fluctuations in intracranial pressure to electrical power through the displacement of a suspended diaphragm with an electrode. To increase the deflection, pressure-instigated phase change of a liquid will be employed to collapse a chamber and effectively amplify the deflection due to the pressure variation. Intellectual Merit: The ability to harvest energy in highly-sensitive areas of the body will allow for a wide range of truly minimally-invasive and autonomous implantable systems which will be able to benefit from the advantages provided by MEMS, nanotechnology, and integrated circuits.Broader Impacts: The broader impacts of this research are numerous with the most significant being the quality of life of people suffering from neurological disorders such as epilepsy, Parkinson's disease, dystonia, essential tremor, and depression. Minimally-invasive and fully autonomous implants can help make these ailments unnoticeable to the patient. In addition, this research will help attract underrepresented groups at the graduate-level through recruitment, and at the undergraduate-level to engineering through exposure of this work to undergraduate students in the classroom and through supervised work, as well as Northeastern University's Building Bridges program with high school students, many of whom are from predominantly minority schools in the area.

本研究的目的是开发一种用于医疗和非医疗应用的能量收集装置。主要重点将是颅内植入式系统，用于治疗神经系统疾病，如癫痫。该方法是通过电极悬挂隔膜的位移将颅内压的波动转换为电能。为了增加偏转，将采用液体的压力引发的相变来使腔室塌陷并有效地放大由于压力变化引起的偏转。智力优势：在身体高度敏感区域收集能量的能力将允许广泛的真正微创和自主植入式系统，这些系统将能够受益于MEMS、纳米技术和集成电路提供的优势。这项研究的广泛影响是众多的，其中最重要的是患有癫痫等神经系统疾病的人的生活质量，帕金森氏病，肌张力障碍，特发性震颤和抑郁症。微创和完全自主的植入物可以帮助使这些疾病对患者不明显。此外，这项研究将有助于吸引代表性不足的群体在研究生层面通过招聘，并在本科层次的工程通过暴露这项工作的本科生在课堂上，并通过监督工作，以及东北大学的建设桥梁计划与高中学生，其中许多人是来自该地区的主要少数民族学校。