DISSERTATION RESEARCH: Experimental investigation of the genomic basis of local adaptation

论文研究：局部适应的基因组基础的实验研究

• 批准号: 0808314
• 负责人: Joy Bergelson
• 金额: $ 1.2万
• 依托单位: University of Chicago
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0808314&HistoricalAwards=false
• 关键词: DISSERTATION; RESEARCH; Experimental; investigation; genomic

Local adaptation is characterized by natural selection for traits that improve fitness under local conditions, irrespective of consequences of these traits in other habitats. Scientists have studied local adaptation via reciprocal transplant experiments: planting individuals of the same species from two different locations together, then assessing if individuals grown at their home site show higher survival and reproduction. However, the extent to which underlying genetic changes contribute to local adaptation remains poorly understood. This research aims to illuminate the genomic basis of local adaptation by pairing reciprocal transplant experiments with genome-wide genetic analysis, using Arabidopsis thaliana plants from different habitats in Sweden. The novelty of this study lies in two areas: the application of cutting-edge genomic resources to plant populations growing in native habitats, and the ability to pinpoint specific regions of the genome associated with survival and reproduction in the field. The researchers will disseminate results, information on rare and isolated populations of A. thaliana, and seed stocks widely to the scientific community. Finally, the value of this research becomes clear when considering the challenges of global climate change, conservation, and habitat restoration in the modern world, all of which touch on the issue of adaptation to specific environmental conditions.

当地适应的特点是自然选择的特点，提高适合当地条件下，不管这些特点在其他栖息地的后果。 科学家们通过相互移植实验研究了当地的适应性：将来自两个不同地点的同一物种的个体种植在一起，然后评估在其家乡生长的个体是否表现出更高的生存率和繁殖率。然而，潜在的遗传变化在多大程度上有助于当地的适应仍然知之甚少。 本研究旨在阐明当地适应的基因组基础配对互惠移植实验与全基因组遗传分析，使用拟南芥植物从不同的栖息地在瑞典。 这项研究的新奇之处在于两个方面：将尖端基因组资源应用于在原生栖息地生长的植物种群，以及确定与野外生存和繁殖相关的基因组特定区域的能力。 研究人员将传播有关罕见和孤立的A. thaliana和种子库广泛地提供给科学界。 最后，当考虑到现代世界全球气候变化、保护和栖息地恢复的挑战时，这项研究的价值变得显而易见，所有这些都涉及到适应特定环境条件的问题。