Effect of Side Chain Length on Intrahelical Ion Pairing Interactions

在化学系有机动力学项目的支持下，纽约州立大学布法罗分校(纽约州立大学布法罗分校)化学系的理查德·P·程教授将进行研究，作为了解带电氨基酸的侧链长度对蛋白质静电相互作用的影响的第一步，这对稳定蛋白质结构、蛋白质-蛋白质和蛋白质-配体识别非常重要。拟议的研究将深入了解为什么自然界中含有不同侧链长度的带电氨基酸，与磷酸丝氨酸的静电相互作用，以及螺旋偶极对螺旋内离子对的影响。这些研究也将为利用不同连接基长度的带电官能团设计多肽、分子和生物技术应用材料奠定基础。这项由布法罗州立大学程教授关于侧链长度对螺旋内静电相互作用的影响的研究将为研究生和本科生提供良好的培训。程？S教授实验室的研究将使学生能够整合多种技术，包括有机合成、固相多肽合成、统计力学和构象分析。拟议研究中的合作将为学生提供与其他科学家互动的机会。研究结果将在专业会议上公布，并在同行评议的科学期刊上发表。程教授还建议制作和播客采访(由学生)科学家最近发表的蛋白质和多肽研究论文。学生将通过采访顶尖科学家和提出深入的问题来接触当前蛋白质和多肽研究的前沿。播客将面向普通公众和学生，目标是传播最新的科学发现，教育普通公众，并招募未来的科学家。

With the support of the Organic Dynamics Program in the Chemistry Division, Professor Richard P. Cheng of the Chemistry Department at the State University of New York at Buffalo (SUNY-Buffalo) will perform research that will serve as a first step towards understanding the effect of side chain length of charged amino acids on protein electrostatic interactions, which are important for stabilizing protein structures, and for protein-protein and protein-ligand recognition. The proposed studies will provide insight into why nature incorporates charged amino acids with varying side chain lengths, electrostatic interactions with phosphoserine, and effects of the helix dipole on intrahelical ion pairs. These studies will also lay the foundation for utilizing charged functionalities with various linker lengths in designing peptides, molecules, and materials for applications in biotechnology.This research by Professor Cheng of SUNY at Buffalo on the effect of side chain length on intrahelical electrostatic interactions will provide excellent training for graduates and undergraduates. Research in Professor Cheng?s lab will enable students to integrate multiple techniques including organic synthesis, solid phase peptide synthesis, and statistical mechanical and conformational analysis. The collaborations in the proposed research will provide students the opportunity to interact with other scientists. The results of the research will be presented at professional meetings and published in peer-reviewed scientific journals. Professor Cheng also proposes to produce and podcast interviews (by students) with scientists on recent publications in protein and peptide research. The students will be exposed to the current frontier of protein and peptide research by interviewing leading scientists and formulating in depth questions. The podcasts will target the general public and students with the goal of distributing recent scientific findings, educating the general public, and recruiting future scientists.