Effect of Side Chain Length on Intrahelical Ion Pairing Interactions

侧链长度对螺旋内离子对相互作用的影响

基本信息

  • 批准号:
    0809633
  • 负责人:
  • 金额:
    $ 36万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-08-01 至 2011-07-31
  • 项目状态:
    已结题

项目摘要

With the support of the Organic Dynamics Program in the Chemistry Division, Professor Richard P. Cheng of the Chemistry Department at the State University of New York at Buffalo (SUNY-Buffalo) will perform research that will serve as a first step towards understanding the effect of side chain length of charged amino acids on protein electrostatic interactions, which are important for stabilizing protein structures, and for protein-protein and protein-ligand recognition. The proposed studies will provide insight into why nature incorporates charged amino acids with varying side chain lengths, electrostatic interactions with phosphoserine, and effects of the helix dipole on intrahelical ion pairs. These studies will also lay the foundation for utilizing charged functionalities with various linker lengths in designing peptides, molecules, and materials for applications in biotechnology.This research by Professor Cheng of SUNY at Buffalo on the effect of side chain length on intrahelical electrostatic interactions will provide excellent training for graduates and undergraduates. Research in Professor Cheng?s lab will enable students to integrate multiple techniques including organic synthesis, solid phase peptide synthesis, and statistical mechanical and conformational analysis. The collaborations in the proposed research will provide students the opportunity to interact with other scientists. The results of the research will be presented at professional meetings and published in peer-reviewed scientific journals. Professor Cheng also proposes to produce and podcast interviews (by students) with scientists on recent publications in protein and peptide research. The students will be exposed to the current frontier of protein and peptide research by interviewing leading scientists and formulating in depth questions. The podcasts will target the general public and students with the goal of distributing recent scientific findings, educating the general public, and recruiting future scientists.
在化学系有机动力学项目的支持下,纽约州立大学布法罗分校化学系的Richard P. Cheng教授(纽约州立大学布法罗分校)将进行研究,这将是了解带电氨基酸侧链长度对蛋白质静电相互作用的影响的第一步,这对稳定蛋白质结构很重要,以及蛋白质-蛋白质和蛋白质-配体识别。拟议的研究将提供深入了解为什么自然结合带电的氨基酸与不同的侧链长度,静电相互作用与磷酸丝氨酸,和螺旋偶极子对intrahelical离子对的影响。这些研究也将为利用不同连接基长度的带电官能团设计生物技术应用的肽、分子和材料奠定基础。布法罗纽约州立大学的郑教授关于侧链长度对螺旋内静电相互作用的影响的研究将为研究生和本科生提供良好的培训。程教授的研究?实验室将使学生能够整合多种技术,包括有机合成,固相肽合成,统计力学和构象分析。在拟议的研究中的合作将为学生提供与其他科学家互动的机会。研究结果将在专业会议上发表,并发表在同行评审的科学期刊上。郑教授亦建议制作和播客(由学生)与科学家就蛋白质和肽研究的最新出版物进行的访谈。学生将通过采访领先的科学家和制定深入的问题,接触到蛋白质和肽研究的最新前沿。播客将面向公众和学生,目的是传播最新的科学发现,教育公众,并招募未来的科学家。

项目成果

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Richard Cheng其他文献

Left atrial to coronary sinus shunting for treatment of heart failure with mildly reduced or preserved ejection fraction: The ALT FLOW Early Feasibility Study 1‐year results
左心房至冠状窦分流治疗射血分数轻度降低或保留的心力衰竭:ALT FLOW 早期可行性研究 1 年结果
  • DOI:
    10.1002/ejhf.3241
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    18.2
  • 作者:
    Marcus A Urey;B. Hibbert;Ulrich P. Jorde;Peter M. Eckman;T. Simard;M. Labinaz;Babak Nazer;Mark Wiley;Bhanu Gupta;A. Sauer;Hirak Shah;P. Sorajja;Andres M Pineda;Emil Missov;E. Mahmud;R. Kahwash;Scott Lilly;A. Latib;Sandhya Murthy;N. Fam;Santiago Garcia;Eugene S Chung;Liviu Klein;Richard Cheng;Brian A Houston;Nicholas S Amoroso;Lee Chang;S. Gafoor;S. Chaudhry;James Hermiller;Jonathan G Schwartz;L. Aldaia;K. Koulogiannis;William A Gray;F. Zahr
  • 通讯作者:
    F. Zahr
THINK BEFORE YOU ACT: AVOIDING THE OCULOSTENOTIC REFLEX IN THE MANAGEMENT OF SPONTANEOUS CORONARY ARTERY DISSECTION
  • DOI:
    10.1016/s0735-1097(19)32835-9
  • 发表时间:
    2019-03-12
  • 期刊:
  • 影响因子:
  • 作者:
    Jeffrey Tyler;Richard Cheng;Saibal Kar
  • 通讯作者:
    Saibal Kar
A SURPRISING CASE OF MELAS IN A PATIENT PRESENTING WITH DECOMPENSATED HEART FAILURE
  • DOI:
    10.1016/s0735-1097(22)04373-x
  • 发表时间:
    2022-03-08
  • 期刊:
  • 影响因子:
  • 作者:
    Gayatri Suresh Kumar;Chris Chaudhary;Richard Cheng;Liviu Klein
  • 通讯作者:
    Liviu Klein
MODERATE OR WORSE VALVE DISEASE AND ADVERSE OUTCOMES AFTER ALLOGENEIC STEM CELL TRANSPLANTATION
  • DOI:
    10.1016/s0735-1097(18)32563-4
  • 发表时间:
    2018-03-10
  • 期刊:
  • 影响因子:
  • 作者:
    Robin Brusen;Richard Cheng;Mohamed Sorror
  • 通讯作者:
    Mohamed Sorror
EFFECT OF REGIONAL VARIATION OF CENTER DENSITY ON HEART TRANSPLANT RISK STRATIFICATION
  • DOI:
    10.1016/s0735-1097(15)60890-7
  • 发表时间:
    2015-03-17
  • 期刊:
  • 影响因子:
  • 作者:
    Vidang Nguyen;Richard Cheng;Claudius Mahr;Nahush Mokadam;Jay Pal;Smith Jason;Todd Dardas
  • 通讯作者:
    Todd Dardas

Richard Cheng的其他文献

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{{ truncateString('Richard Cheng', 18)}}的其他基金

Instructional Scientific Equipment Program
教学科学设备计划
  • 批准号:
    7511473
  • 财政年份:
    1975
  • 资助金额:
    $ 36万
  • 项目类别:
    Standard Grant

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    27.0 万元
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    青年科学基金项目

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