Chiral Porous Materials for Enantioselective Catalysis and Separations

用于对映选择性催化和分离的手性多孔材料

• 批准号: 0809776
• 负责人: Wenbin Lin
• 金额: $ 45万
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0809776&HistoricalAwards=false
• 关键词: Chiral; Porous; Materials; Enantioselective; Catalysis

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports research by Professor Wenbin Lin at the University of North Carolina to develop rational synthetic strategies toward homochiral and highly porous metal-organic coordination networks (MOCNs) and to explore their applications in heterogeneous asymmetric catalysis and chiral separations. Three key issues concerning heterogeneous asymmetric catalysts based on homochiral porous MOCNs will be addressed: rational synthesis of homochiral MOCNs with permanent porosity and appropriate functionalities, development of novel strategies for the synthesis of highly porous homochiral MOCNs from typically unresolvable (achiral) building blocks, and the utilities of homochiral porous MOCNs in practical enantioselective catalysis and separations. Highly porous chiral MOCNs with desirable functional groups and appropriate metal linkers will result from the proposed research, which should possess tailorable chiral pockets and functionalities that are exploitable for enantioselective separations and catalysis. The proposed research will develop new bottom-up approaches towards efficient heterogeneous asymmetric catalysts that can be readily recycled and re-used and can prevent the leaching of often toxic metals from the catalysts into the organic products. Graduate students and postdoctoral research associates participating in the proposed interdisciplinary research will be trained with the skills that are crucial to their future careers as Ph.D. chemists. The proposed research will also be integrated into the training of undergraduates and high school students.

无机，生物无机和有机化学计划的这一奖项支持北卡罗来纳州大学林文斌教授的研究，以开发合理的合成策略，实现纯手性和高度多孔的金属有机配位网络（MOCN），并探索其在非均相不对称催化和手性分离中的应用。基于同手性多孔MOCN的非均相不对称催化剂的三个关键问题将得到解决：具有永久孔隙率和适当功能的同手性MOCN的合理合成，从典型的不可拆分（非手性）构建块合成高度多孔的同手性MOCN的新策略的发展，以及同手性多孔MOCN在实际的对映选择性催化和分离中的效用。具有所需官能团和适当的金属连接体的高度多孔的手性MOCN将从所提出的研究中产生，其应具有可用于对映选择性分离和催化的可定制的手性口袋和官能团。拟议的研究将开发新的自下而上的方法，以实现高效的多相不对称催化剂，这些催化剂可以很容易地回收和再利用，并可以防止有毒金属从催化剂中浸出到有机产品中。参加拟议的跨学科研究的研究生和博士后研究助理将接受培训，掌握对他们未来的博士生涯至关重要的技能。化学家。拟议的研究也将纳入本科生和高中生的培训。