Chiral Porous Metal-Organic Frameworks as A Tunable Platform for Asymmetric Catalysis

国家科学基金会化学部的化学催化计划将支持查佩尔山的北卡罗来纳州大学的林文斌教授的研究计划。 林博士和他的学生正在探索使用将活性均相催化剂纳入金属有机框架材料的策略来合成对映选择性催化剂。这些“多相化”均相催化剂的特征在于活性和选择性，并且从染料吸收/光谱法和X-射线衍射获得的关于催化剂结构的信息用于设计改进的催化材料。 新的方法，特别是使用染料敏化的光学探针来确定孔径，和新的合成方法，其中包括在MOF合成路线的功能框架成员，将导致从这项工作。 此外，将产生活性对映选择性催化剂材料。 这些催化材料将用于精细化学品、药物化学中间体的合成，以及用于药物的立体定向工艺路线的设计。 高中生将与本科生和研究生一起参加这个广泛的多学科研究项目。

The Chemical Catalysis Program of the Chemistry Division of the National Science Foundation will support the research program of Professor Wenbin Lin of the University of North Carolina at Chapel Hill. Dr. Lin and his students are exploring the synthesis of enantioselective catalysts using strategies to incorporate active homogeneous catalysts into metal-organic framework materials. These "heterogenized" homogeneous catalysts are characterized for activity and selectivity, and information about the catalyst structure obtained from dye absorption/spectrometry and X-ray diffraction are used to design improved catalytic materials. New methodology, specifically the use of dye sensitized optical probes to determine pore size, and new synthetic approaches, which include functional framework members in the MOF synthetic routes, will result from this work. In addition, active enanatioselective catalyst materials will be produced. These catalytic materials will be useful for the synthesis of fine chemicals, medicinal chemistry intermediates, and for the design of stereospecific process routes for pharmaceuticals. High school students will work alongside undergraduate and graduate students in this broadly multidisciplinary research program.