Chiral Porous Materials for Enantioselective Catalysis and Separations

北卡罗来纳大学教堂山分校化学系林文斌博士在化学部无机化学、生物无机化学和金属有机化学项目的支持下，致力于发展同手性多孔固体的合理合成策略，并探索这些材料在多相不对称催化和手性分离中的应用。介绍了同手性多孔金属有机配位网络(MOCNs)的三个关键问题，即具有永久孔隙率和合适功能的同手性多金属有机配位网络(MOCNs)的合理合成，了解同手性多孔金属有机配位网络在催化条件下的骨架稳定性，以及同手性多孔金属有机配位网络在实际对映选择性催化和分离中的应用。这些手性多孔材料将结合多相催化剂的优点(如催化剂回收和重复使用)和均相催化剂的优点(如活性中心的均一性和选择性)。多相催化负责大多数商品化学品的生产，是化学工业的基石。该项目从根本上探索了新型多相不对称催化剂的自下而上的方法，这种催化剂可以很容易地回收和重复使用，并可以防止往往有毒的金属从催化剂中浸出到有机产品中。这种具有催化活性的同手性有机碳纳米管可以经济地生产许多用于制药、农用化学品和香料工业的手性化合物。参与拟议跨学科研究的研究生和博士后研究助理将接受培训，掌握对他们未来的博士化学家职业生涯至关重要的技能。拟议的研究还将纳入本科生和高中生的培训。

Dr. Wenbin Lin, Department of Chemistry, University of North Carolina - Chapel Hill, is supported by the Inorganic, Bioinorganic and Organometallic Chemistry Program of the Chemistry Division for the development of rational synthetic strategies toward homochiral porous solids and the exploration of these materials in heterogeneous asymmetric catalysis and chiral separations. Three key issues concerning homochiral porous metal-organic coordination networks (MOCNs) will be addressed, namely, rational synthesis of homochiral MOCNs with permanent porosity and appropriate functionalities, understanding of the framework stability of homochiral porous MOCNs under catalytic conditions, and the utilitization of homochiral porous MOCNs in practical enantioselective catalysis and separations. These chiral porous materials will combine the advantages offered by heterogeneous catalysts (such as catalyst recycle and re-use) and those offered by their homogeneous counterparts (such as homogeneity of active sites and selectivity). Heterogeneous catalysis is responsible for the production of the majority of commodity chemicals and is a cornerstone of the chemical industry. This project explores fundamentally new bottom-up approaches towards novel heterogeneous asymmetric catalysts which can be readily recycled and re-used and can prevent the leaching of often toxic metals from the catalysts into the organic products. Such catalytically-active homochiral MOCNs can lead to economical production of many chiral compounds for the pharmaceutical, agrochemical, and fragrance industries. Graduate students and postdoctoral research associates participating in the proposed interdisciplinary research will be trained with the skills that are crucial to their future careers as Ph.D. chemists. The proposed research will also be integrated into the training of undergraduates and high school students.