Chiral Porous Materials for Enantioselective Catalysis and Separations

北卡罗来纳州-查佩尔山大学化学系的林文斌博士得到化学系无机、生物无机和有机化学项目的支持，致力于开发同手性多孔固体的合理合成策略，并探索这些材料在非均相不对称催化和手性分离中的应用。本论文将讨论同手性多孔金属有机配位网络（MOCN）的三个关键问题，即合理合成具有永久孔隙率和适当功能性的同手性MOCN，理解同手性多孔MOCN在催化条件下的骨架稳定性，以及同手性多孔MOCN在实际对映选择性催化和分离中的应用。这些手性多孔材料将联合收割机结合由非均相催化剂提供的优点（例如催化剂再循环和再使用）和由其均相对应物提供的优点（例如活性位点的均匀性和选择性）。多相催化是大多数化学品的生产过程，是化学工业的基石。该项目从根本上探索了新的自下而上的方法，以获得新型多相不对称催化剂，这些催化剂可以很容易地回收和再利用，并可以防止有毒金属从催化剂中浸出到有机产品中。这种催化活性的纯手性MOCN可以导致用于制药、农用化学品和香料工业的许多手性化合物的经济生产。参加拟议的跨学科研究的研究生和博士后研究助理将接受培训，掌握对他们未来的博士生涯至关重要的技能。化学家拟议的研究也将纳入本科生和高中生的培训。

Dr. Wenbin Lin, Department of Chemistry, University of North Carolina - Chapel Hill, is supported by the Inorganic, Bioinorganic and Organometallic Chemistry Program of the Chemistry Division for the development of rational synthetic strategies toward homochiral porous solids and the exploration of these materials in heterogeneous asymmetric catalysis and chiral separations. Three key issues concerning homochiral porous metal-organic coordination networks (MOCNs) will be addressed, namely, rational synthesis of homochiral MOCNs with permanent porosity and appropriate functionalities, understanding of the framework stability of homochiral porous MOCNs under catalytic conditions, and the utilitization of homochiral porous MOCNs in practical enantioselective catalysis and separations. These chiral porous materials will combine the advantages offered by heterogeneous catalysts (such as catalyst recycle and re-use) and those offered by their homogeneous counterparts (such as homogeneity of active sites and selectivity). Heterogeneous catalysis is responsible for the production of the majority of commodity chemicals and is a cornerstone of the chemical industry. This project explores fundamentally new bottom-up approaches towards novel heterogeneous asymmetric catalysts which can be readily recycled and re-used and can prevent the leaching of often toxic metals from the catalysts into the organic products. Such catalytically-active homochiral MOCNs can lead to economical production of many chiral compounds for the pharmaceutical, agrochemical, and fragrance industries. Graduate students and postdoctoral research associates participating in the proposed interdisciplinary research will be trained with the skills that are crucial to their future careers as Ph.D. chemists. The proposed research will also be integrated into the training of undergraduates and high school students.