Chiral Porous Materials for Enantioselective Catalysis and Separations

林文斌博士，北卡罗来纳大学教堂山分校化学系，受化学学部无机、生物无机和有机金属化学项目的支持，致力于开发针对同手性多孔固体的合理合成策略，并探索这些材料在非均质不对称催化和手性分离中的应用。本文将讨论有关同手性多孔金属有机配位网络的三个关键问题，即合理合成具有永久孔隙和适当功能的同手性多孔金属有机配位网络，了解催化条件下同手性多孔金属有机配位网络的框架稳定性，以及在实际对映选择性催化和分离中的应用。这些手性多孔材料将结合非均相催化剂（如催化剂的回收和再利用）和均相催化剂（如活性位点的均匀性和选择性）的优点。多相催化负责大多数商品化学品的生产，是化学工业的基石。该项目从根本上探索了新的自下而上的方法，以实现新型多相不对称催化剂，这种催化剂可以很容易地回收和再利用，并且可以防止催化剂中的有毒金属浸出到有机产品中。这种具有催化活性的同手性cmon可以经济地生产许多用于制药，农用化学品和香料工业的手性化合物。参与拟议跨学科研究的研究生和博士后研究助理将接受技能培训，这对他们未来作为博士化学家的职业生涯至关重要。建议的研究也将整合到本科生和高中生的培训中。

Dr. Wenbin Lin, Department of Chemistry, University of North Carolina - Chapel Hill, is supported by the Inorganic, Bioinorganic and Organometallic Chemistry Program of the Chemistry Division for the development of rational synthetic strategies toward homochiral porous solids and the exploration of these materials in heterogeneous asymmetric catalysis and chiral separations. Three key issues concerning homochiral porous metal-organic coordination networks (MOCNs) will be addressed, namely, rational synthesis of homochiral MOCNs with permanent porosity and appropriate functionalities, understanding of the framework stability of homochiral porous MOCNs under catalytic conditions, and the utilitization of homochiral porous MOCNs in practical enantioselective catalysis and separations. These chiral porous materials will combine the advantages offered by heterogeneous catalysts (such as catalyst recycle and re-use) and those offered by their homogeneous counterparts (such as homogeneity of active sites and selectivity). Heterogeneous catalysis is responsible for the production of the majority of commodity chemicals and is a cornerstone of the chemical industry. This project explores fundamentally new bottom-up approaches towards novel heterogeneous asymmetric catalysts which can be readily recycled and re-used and can prevent the leaching of often toxic metals from the catalysts into the organic products. Such catalytically-active homochiral MOCNs can lead to economical production of many chiral compounds for the pharmaceutical, agrochemical, and fragrance industries. Graduate students and postdoctoral research associates participating in the proposed interdisciplinary research will be trained with the skills that are crucial to their future careers as Ph.D. chemists. The proposed research will also be integrated into the training of undergraduates and high school students.