Chiral Porous Metal-Organic Frameworks as A Tunable Platform for Asymmetric Catalysis

国家科学基金化学部化学催化计划将支持北卡罗来纳大学教堂山分校林文斌教授的研究计划。林博士和他的学生正在探索合成对映体选择性催化剂的方法，方法是将活性均相催化剂引入金属-有机骨架材料。对这些“多相”均相催化剂的活性和选择性进行了表征，并利用从染料吸收/光谱分析和X射线衍射获得的关于催化剂结构的信息来设计改进的催化材料。这项工作将产生新的方法，特别是使用染料敏化的光学探针来确定孔径大小，以及新的合成方法，其中包括MOF合成路线中的功能框架成员。此外，还将生产活性烷基选择性催化剂材料。这些催化材料将用于精细化学品的合成、药物化学中间体的合成以及药物立体定向工艺路线的设计。高中生将在这个广泛的多学科研究项目中与本科生和研究生一起工作。

The Chemical Catalysis Program of the Chemistry Division of the National Science Foundation will support the research program of Professor Wenbin Lin of the University of North Carolina at Chapel Hill. Dr. Lin and his students are exploring the synthesis of enantioselective catalysts using strategies to incorporate active homogeneous catalysts into metal-organic framework materials. These "heterogenized" homogeneous catalysts are characterized for activity and selectivity, and information about the catalyst structure obtained from dye absorption/spectrometry and X-ray diffraction are used to design improved catalytic materials. New methodology, specifically the use of dye sensitized optical probes to determine pore size, and new synthetic approaches, which include functional framework members in the MOF synthetic routes, will result from this work. In addition, active enanatioselective catalyst materials will be produced. These catalytic materials will be useful for the synthesis of fine chemicals, medicinal chemistry intermediates, and for the design of stereospecific process routes for pharmaceuticals. High school students will work alongside undergraduate and graduate students in this broadly multidisciplinary research program.