Collaborative Research: Abiotic Stress Combination: Bridging the gap between Arabidopsis Stress Research and Agriculture

拟南芥2010：非生物胁迫组合：弥合拟南芥胁迫研究与农业之间的差距本项目开展的工作旨在为2010年计划的目标做出重大贡献-了解拟南芥中每个基因的网络和功能。该项目的具体重点是非生物胁迫组合以及对干旱和高温、干旱和盐度以及盐度和高温等胁迫组合作出反应的遗传和代谢网络。非生物胁迫是全球作物损失的主要原因，美国每年的损失估计为140 - 190亿美元。虽然在拟南芥中，非生物胁迫通常是通过施加单一的胁迫条件（如干旱、盐度或高温）来研究的，但这种类型的分析并不能反映出作物植物受到不同胁迫组合的田间条件。该项目的中心目标是确定新的基因，基因网络和代谢途径，专门响应两种不同的非生物胁迫的组合。要测试的假设是，在同时暴露于两种不同压力条件下的植物中，专用基因、网络和途径被激活。本项目旨在将拟南芥带入非生物抗逆性应用研究的前沿，弥合实验室中利用拟南芥进行的胁迫研究与田间影响作物的条件之间的差距。拟议研究的两个关键“更广泛的影响”是：1)开发和维护一个集中的网站，将农学家、育种家和拟南芥分子生物学家聚集在一起（http://www.ag.unr.edu/Stress_Combination/）。2)对博士后、研究生和本科生进行K-12教育推广和多学科培训。本科和K-12的拓展和培训活动将针对弱势群体和在科学领域代表性不足的群体。从历史上看，干旱和高温等非生物胁迫组合对美国的经济和社会影响最为严重，1980年和1988年的损失分别为484亿美元和616亿美元。拟议的项目将为开发具有增强非生物抗逆性的作物铺平道路，有助于改善由于预期的气候变化而可能增加频率的未来天气灾害的后果。

Arabidopsis 2010: Abiotic stress combination: Bridging the gap between Arabidopsis stress research and agricultureThe work undertaken on this project is designed to make significant contributions to the goals of the 2010 program - to understand the networking and function of every gene in Arabidopsis. The specific focus of the project is on abiotic stress combinations and the genetic and metabolic networks that respond to stress combinations such as drought and heat, drought and salinity and salinity and heat. Abiotic stress is the primary cause of crop loss world-wide, with losses in the US estimated at 14-19 billion dollars each year. While abiotic stress is routinely studied in Arabidopsis by applying a single stress condition such as drought, salinity or heat, this type of analysis does not reflect the conditions that occur in the field where crop plants are subjected to a combination of different stresses. The central objective of the project is to identify novel genes, gene networks and metabolic pathways that specifically respond to a combination of two different abiotic stresses. The hypothesis to be tested is that dedicated genes, networks and pathways are activated in plants that are simultaneously exposed to two different stress conditions. This project is designed to bring Arabidopsis into the front line of applied research on abiotic stress tolerance, and bridge the gap between stress studies conducted with Arabidopsis in the lab and the conditions that impact crops in the field. The two key "Broader Impacts" of the proposed research are: 1) Development and maintenance of a centralized website that will bring together agronomists, breeders and Arabidopsis molecular biologists (http://www.ag.unr.edu/Stress_Combination/). 2) Educational outreach for K-12 and multidisciplinary training to postdoctoral, graduate and undergraduates trainees. Both undergraduate and K-12 outreach and training activities will target the under privileged and under represented in Science. Historically, abiotic stress combinations, such as drought and heat, had the outmost devastating economical and sociological impacts on the US, with losses of 48.4 and 61.6 billion dollars in 1980 and 1988 respectively. The proposed project will pave the way for the development of crops with enhanced abiotic stress tolerance, contributing to ameliorate the consequences of future weather disasters that are likely to increase in frequency due to anticipated climatic changes.