Collaborative Research: Abiotic Stress Combination: Bridging the gap between Arabidopsis Stress Research and Agriculture

拟南芥2010：非生物胁迫组合：弥合拟南芥胁迫研究和农业之间的差距该项目的工作旨在为2010年计划的目标做出重大贡献-了解拟南芥中每个基因的网络和功能。该项目的具体重点是非生物应激组合以及对干旱和高温、干旱和盐分以及盐分和高温等应激组合作出反应的遗传和代谢网络。非生物压力是全球农作物损失的主要原因，据估计，美国每年损失140-190亿美元。虽然在拟南芥中，非生物胁迫通常是通过应用单一的胁迫条件来研究的，如干旱、盐分或高温，但这种类型的分析并不反映作物遭受不同胁迫组合的田间条件。该项目的中心目标是确定对两种不同的非生物胁迫组合做出具体反应的新基因、基因网络和代谢途径。需要检验的假设是，在同时暴露于两种不同胁迫条件下的植物中，特定的基因、网络和途径被激活。该项目旨在将拟南芥带入非生物抗逆性应用研究的第一线，并弥合在实验室对拟南芥进行的胁迫研究与影响田间作物的条件之间的差距。拟议研究的两个关键的“更广泛的影响”是：1)开发和维护一个集中的网站，该网站将汇集农艺学家、育种学家和拟南芥分子生物学家(http://www.ag.unr.edu/Stress_Combination/).2)K-12教育外展和对博士后、研究生和本科生实习生的多学科培训。本科生和K-12的外展和培训活动都将针对在科学领域处于不利地位和代表性不足的人。从历史上看，干旱和高温等非生物压力组合对美国的经济和社会影响是最具破坏性的，1980年和1988年分别造成了484亿美元和616亿美元的损失。拟议的项目将为开发具有增强的非生物胁迫耐受性的作物铺平道路，有助于缓解未来天气灾害的后果，这些灾害可能会因预期的气候变化而增加。

Arabidopsis 2010: Abiotic stress combination: Bridging the gap between Arabidopsis stress research and agricultureThe work undertaken on this project is designed to make significant contributions to the goals of the 2010 program - to understand the networking and function of every gene in Arabidopsis. The specific focus of the project is on abiotic stress combinations and the genetic and metabolic networks that respond to stress combinations such as drought and heat, drought and salinity and salinity and heat. Abiotic stress is the primary cause of crop loss world-wide, with losses in the US estimated at 14-19 billion dollars each year. While abiotic stress is routinely studied in Arabidopsis by applying a single stress condition such as drought, salinity or heat, this type of analysis does not reflect the conditions that occur in the field where crop plants are subjected to a combination of different stresses. The central objective of the project is to identify novel genes, gene networks and metabolic pathways that specifically respond to a combination of two different abiotic stresses. The hypothesis to be tested is that dedicated genes, networks and pathways are activated in plants that are simultaneously exposed to two different stress conditions. This project is designed to bring Arabidopsis into the front line of applied research on abiotic stress tolerance, and bridge the gap between stress studies conducted with Arabidopsis in the lab and the conditions that impact crops in the field. The two key "Broader Impacts" of the proposed research are: 1) Development and maintenance of a centralized website that will bring together agronomists, breeders and Arabidopsis molecular biologists (http://www.ag.unr.edu/Stress_Combination/). 2) Educational outreach for K-12 and multidisciplinary training to postdoctoral, graduate and undergraduates trainees. Both undergraduate and K-12 outreach and training activities will target the under privileged and under represented in Science. Historically, abiotic stress combinations, such as drought and heat, had the outmost devastating economical and sociological impacts on the US, with losses of 48.4 and 61.6 billion dollars in 1980 and 1988 respectively. The proposed project will pave the way for the development of crops with enhanced abiotic stress tolerance, contributing to ameliorate the consequences of future weather disasters that are likely to increase in frequency due to anticipated climatic changes.