MRI: Acquistion of Femtosecond UV-Laser Ablation System for Elemental & Isotopic Mapping by Hyphenated Sector Field ICP-MS

MRI：获取用于元素的飞秒紫外激光消融系统

• 批准号: 0821304
• 负责人: Lee Goldstein
• 金额: $ 20万
• 依托单位: Trustees of Boston University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0821304&HistoricalAwards=false
• 关键词: MRI; Acquistion; Femtosecond; UV; Laser

CBET-0821304GoldsteinThis NSF Major Research Instrumentation project requests funding for a femtosecond laser ablation (LA) solid sampling system for analytical coupling ("hyphenation") to a newly-acquired magnetic sector field inductively-coupled plasma mass spectrometer (SF-ICP-MS). The grant hyphenated LA-SF-ICP-MS system is intended for high-resolution two-dimensional elemental and isotopic profiling in a diverse range of materials and research applications. The system will greatly expand the analytical capabilities of the recently-established Center for Biometals and Metallomics (CBM), a unique multidisciplinary analytical facility at the Boston University School of Medicine and College of Engineering. The CBM is the only dedicated facility of its kind in the nation. The centerpiece of the facility is a stateof- the-art SF-ICP-MS instrument acquired through a Shared Instrument Grant funded by the National Center for Research Resources, NIH. This powerful instrument is the gold standard for definitive ultra-trace elemental and isotopic analyses in a wide variety of matrices. Deployment of the proposed hyphenated analytical instrumentation will provide researchers locally and throughout the region with an unparalleled analytical resource that will accelerate lead-edge discovery in a wide range of fields.Funds are requested for instrument acquisition to hyphenate the SF-ICP-MS instrument with a powerful and complementary technology, high-resolution laser ablation solid sampling. The proposed system couples definitive elemental and isotopic analysis with high-resolution femtosecond laser-assisted spatial sampling for wide-ranging application involving a variety of material substrates. The application proposes to address new questions with new technologies coupled in new ways and capitalizes on presently available analytical capabilities and interdisciplinary expertise. Collaborations that will benefit through use of the hyphenated analytical instrumentation include the Museum of Fine Arts, Boston, Lawrence Berkeley National Laboratory, Museum of Ireland, Harvard and Boston University Schools of Public Health, and the US Geological Service, amongst others. Access will be open to qualified students, staff, and researchers throughout the region who require this advanced analytical instrumentation for scientific inquiry. Senior scientists, postgraduate researchers, graduate students, undergraduates, and facility staff will be directly involved in utilizing the requested instrumentation. The hyphenated system will be managed as a shared-collaborative user resource allied to other significant institutional analytical facilities, including the Boston University Mass Spectrometry Resource. A strong emphasis will be placed on interdisciplinary interaction as well as education and training. Facility staff will develop training courses, facilitate analytical protocol development, assist collaborating scientists with experimental design and execution, and organize internal and external conferences to promote the use of advanced mass spectrometry instrumentation and allied hyphenated technologies for application in a wide array of research programs and applications. Educational activities at the high school, undergraduate, graduate, and post-graduate levels will be integrated with ongoing analytical operations to facilitate both formal and informal interaction amongst students, trainees, senior investigators, and resource staff. Regional, national, and international scientific exchange is already operative and is expected to expand with project funding. Novel utilization, pilot experimentation and technology development will be encouraged to open new and expanded research opportunities using LA-ICP-MS instrumentation.

CBET-0821304 Goldstein该NSF重大研究仪器项目要求为飞秒激光烧蚀(LA)固体采样系统申请资金，用于分析与新获得的磁扇区场电感耦合等离子体质谱仪(SF-ICPMS)的耦合(“联用”)。GRANT联用的LA-SF-ICP-MS系统旨在用于各种材料和研究应用中的高分辨率二维元素和同位素剖析。该系统将极大地扩展最近成立的生物金属和金属组学中心(CBM)的分析能力，CBM是波士顿大学医学院和工程学院的独特的多学科分析设施。CBM是美国唯一的此类专用设施。该设施的中心是一台最先进的SF-ICPMS仪器，该仪器是由美国国立卫生研究院国家研究资源中心资助的共享仪器赠款获得的。这一功能强大的仪器是各种基质中确定的超痕量元素和同位素分析的黄金标准。拟议的联用分析仪器的部署将为当地和整个地区的研究人员提供无与伦比的分析资源，这将加速在广泛领域发现前沿。需要为仪器采购提供资金，以便将SF-ICPMS仪器与强大的补充技术、高分辨率激光烧蚀固体采样连接起来。该系统将确定的元素和同位素分析与高分辨率飞秒激光辅助空间采样结合在一起，可用于涉及各种材料基质的广泛应用。该应用程序建议以新的方式结合新技术解决新问题，并利用目前可用的分析能力和跨学科专业知识。将通过使用联用分析仪器而受益的合作机构包括波士顿美术馆、劳伦斯伯克利国家实验室、爱尔兰博物馆、哈佛大学和波士顿大学公共卫生学院以及美国地质服务机构等。访问将向整个地区合格的学生、教职员工和研究人员开放，这些学生、教职员工和研究人员需要这种先进的分析工具进行科学研究。资深科学家、研究生研究人员、研究生、本科生和设施工作人员将直接参与使用所要求的仪器。联号系统将作为共享协作用户资源进行管理，与包括波士顿大学质谱学资源在内的其他重要机构分析机构结盟。将高度重视跨学科互动以及教育和培训。设施工作人员将开发培训课程，促进分析方案的开发，协助合作科学家进行实验设计和执行，并组织内部和外部会议，以促进先进的质谱仪和相关联用技术在广泛的研究计划和应用中的应用。高中、本科生、研究生和研究生层面的教育活动将与持续的分析操作相结合，以促进学生、实习生、高级调查人员和资源人员之间的正式和非正式互动。区域、国家和国际科学交流已经开始运作，并有望随着项目资金的增加而扩大。将鼓励新的利用、中试实验和技术开发，以打开使用LA-ICPMS仪器的新的和扩大的研究机会。