CRC: Nanoscale Assembly of Biomolecular Complexes

CRC：生物分子复合物的纳米级组装

• 批准号: 0832651
• 负责人: Martin Jarrold
• 金额: $ 292.5万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0832651&HistoricalAwards=false
• 关键词: CRC; Nanoscale; Assembly; Biomolecular; Complexes

Professors Martin F. Jarrold, Bogdan Dragnea, Stephen C. Jacobson, Peter J. Ortoleva, and James P. Reilly at Indiana University are supported by the Collaborative Research in Chemistry Program to address how supramolecular assemblies, such as viruses, are built from their component macromolecules as well as how structural transitions occur in the assembled complexes. The self-assembly of supramolecular complexes spans time scales from nanoseconds to hundreds of seconds and length scales from nanometers to micrometers. Intermediates in these processes will be monitored by interfacing current and new mass spectrometry techniques with microfluidic devices capable of reaction control and opto-electronic detection. Experimental studies are integrated with a multi-scale theoretical approach. The new methodologies are being tested on simple icosahedral viruses. The highly collaborative approach taken in this program will provide graduate students and postdoctoral researchers with cross-disciplinary training, positioning them to make significant scientific and technical contributions. Talented undergraduate students from Rose-Hulman Institute of Technology and Prairie View A&M University work at Indiana University during the summer months and continue their projects at their home institutions with the assistance of collaborating faculty during the academic year. Tutorials on the use of multiscale simulation software will be produced and made available by the Indiana University Nanoscience Center.

Martin F.放大图片作者：Stephen C.印第安纳州大学的Jacobson，Peter J. Ortoleva和James P. Reilly得到了化学合作研究计划的支持，以解决超分子组装体（如病毒）如何从其组成的大分子中构建，以及组装的复合物中如何发生结构转变。 超分子复合物的自组装跨越了从纳秒到数百秒的时间尺度和从纳米到微米的长度尺度。 这些过程中的中间体将通过将当前和新的质谱技术与能够进行反应控制和光电检测的微流控装置相结合来监测。 实验研究与多尺度理论方法相结合。新的方法正在简单的二十面体病毒上进行测试。该计划采取的高度协作的方法将为研究生和博士后研究人员提供跨学科培训，使他们能够做出重大的科学和技术贡献。 从技术和草原视图A M大学的罗斯-休曼研究所的优秀本科生工作在印第安纳州大学在夏季的几个月里，并继续在他们的家庭机构的合作教师在学年的协助下，他们的项目。多尺度模拟软件的使用教程将由印第安纳州大学纳米科学中心制作和提供。