CRC: Nanoscale Assembly of Biomolecular Complexes

印第安纳大学的马丁·F·雅罗尔德、博格丹·德拉格尼亚、斯蒂芬·C·雅各布森、彼得·J·奥托列娃和詹姆斯·P·赖利教授得到化学合作研究计划的支持，研究病毒等超分子组件是如何从其组成的大分子构建起来的，以及如何在组装的复合体中发生结构转变。超分子复合体的自组装时间跨度从纳秒到数百秒，长度从纳米到微米。这些过程中的中间体将通过将当前和新的质谱学技术与能够进行反应控制和光电检测的微流控设备连接起来进行监测。实验研究与多尺度理论方法相结合。新方法正在简单的二十面体病毒上进行测试。该项目采取的高度协作的方法将为研究生和博士后研究人员提供跨学科培训，使他们能够做出重大的科学和技术贡献。来自Rose-Hulman理工学院和Prairie View A&amp；M大学的有才华的本科生在夏季的几个月里在印第安纳大学工作，并在学年期间在合作教师的帮助下在各自的机构继续他们的项目。印第安纳大学纳米科学中心将制作和提供使用多尺度模拟软件的教程。

Professors Martin F. Jarrold, Bogdan Dragnea, Stephen C. Jacobson, Peter J. Ortoleva, and James P. Reilly at Indiana University are supported by the Collaborative Research in Chemistry Program to address how supramolecular assemblies, such as viruses, are built from their component macromolecules as well as how structural transitions occur in the assembled complexes. The self-assembly of supramolecular complexes spans time scales from nanoseconds to hundreds of seconds and length scales from nanometers to micrometers. Intermediates in these processes will be monitored by interfacing current and new mass spectrometry techniques with microfluidic devices capable of reaction control and opto-electronic detection. Experimental studies are integrated with a multi-scale theoretical approach. The new methodologies are being tested on simple icosahedral viruses. The highly collaborative approach taken in this program will provide graduate students and postdoctoral researchers with cross-disciplinary training, positioning them to make significant scientific and technical contributions. Talented undergraduate students from Rose-Hulman Institute of Technology and Prairie View A&M University work at Indiana University during the summer months and continue their projects at their home institutions with the assistance of collaborating faculty during the academic year. Tutorials on the use of multiscale simulation software will be produced and made available by the Indiana University Nanoscience Center.