NIRT: Stimuli-responsive hybrid nanoparticles for controlled chemical delivery

建议没有。题目：NIRT：用于受控化学输送的刺激响应型混合纳米颗粒ypi: Hamid ghandehari机构：马里兰大学巴尔的摩分校摘要知识优势：该提案收到于纳米尺度科学与工程计划，NSF 05-610， NIRT类别。本研究的目的是构建混合刺激反应纳米颗粒，用于控制生物活性药物的递送。该方法是：i)制造由金、二氧化硅或其复合材料制成的多孔纳米颗粒，并与基因工程的刺激敏感聚合物接枝；ii)评估生物分子的负载、扩散和释放作为环境条件（pH值、温度）的函数。受控药物输送系统传统上使用化学合成的聚合物基材料。对聚合物结构的控制是一个主要的挑战，它会影响它们在体内携带和释放药物的能力。显然需要开发先进的系统，对其以可预测的方式释放治疗有效载荷的能力进行更高程度的控制。目前的研究提出了一种由热响应和pH响应的重组聚合物制成的表面有“开关”孔帽的杂化无机多孔纳米颗粒的制造方法。在体温和中性的血液pH值下，聚合物会在颗粒孔上坍塌，阻止药物释放。在pH值降低的环境中（如肿瘤内部和周围的环境），聚合物将被溶解，从而允许药物释放。更广泛的影响：这些混合纳米结构提供了强大的无机核心的好处，一方面，它们的大小和孔隙度在生物环境中不会改变，另一方面，柔性表面接枝聚合物允许控制药物释放。纳米平台可广泛应用于输送、传感、分离、诊断等智能材料应用领域。这个项目的教育部分将有助于培养新一代的学生和科学家，他们将能够在基础科学和应用科学的界面上工作，设计用于生物医学应用的新型纳米结构。

Proposal No.: 0608906Title: NIRT: Stimuli-responsive hybrid nanoparticles for controlled chemical deliveryPI: Hamid GhandehariInstitution: University of Maryland at BaltimoreABSTRACTIntellectual Merit:This proposal was received in response to Nanoscale Science and Engineering initiative, NSF 05-610, category NIRT. The objective of this research is to construct hybrid stimuli-responsive nanoparticles for controlled delivery of bioactive agents. The approach is to: i) fabricate porous nanoparticles made of gold, silica or composites thereof grafted with genetically engineered stimuli-sensitive polymers and ii) evaluate biomolecule loading, diffusion, and release from the nanoconstructs as a function of environmental conditions (pH, temperature).Controlled drug delivery systems traditionally use chemically synthesized polymer-based materials. Control over polymer structure is a major challenge, which affects their ability to carry and release drugs in the body. There is a clear need to develop advanced systems with a higher degree of control over their ability to release the therapeutic payload in a predictable manner. The current research proposes the fabrication of hybrid inorganic porous nanoparticles with "on-off" pore caps on their surface made of thermal and pH - responsive recombinant polymers. At body temperature and neutral pH of the blood stream the polymers will be collapsed over the particle pores preventing drug release. In the decreased pH environment (such as that in and around a tumor) the polymers will be solubilized, allowing drug release. Broader Impacts:These hybrid nanostructures provide the benefit of robust inorganic cores on one hand where their size and porosity do not change in biological environments, and the flexible surface grafted polymers on the other allowing controlled drug release. The nanoplatforms can be broadly applied in delivery, sensing, separation, diagnostics and other areas where smart materials are utilized. The educational component of this project will facilitate training of new generations of students and scientists who will be able to work at the interface of basic and applied sciences for the design of novel nanoconstructs for use in biomedical applications.