NIRT: Stimuli-responsive hybrid nanoparticles for controlled chemical delivery

方案编号： 0608906职务：NIRT：刺激响应混合纳米粒子控制化学品deliveryPI：哈米德Ghandehari机构：马里兰州巴尔的摩大学摘要智力优点：这个建议是在响应纳米科学和工程倡议，NSF 05-610，类别NIRT。本研究的目的是构建混合刺激响应纳米粒子的生物活性剂的控制输送。办法是：i）制造由接枝有遗传工程刺激敏感聚合物的金、二氧化硅或其复合物制成的多孔纳米颗粒，和ii）评估作为环境条件（pH、温度）的函数的生物分子负载、扩散和从纳米结构释放。对聚合物结构的控制是一个重大挑战，这影响了它们在体内携带和释放药物的能力。显然需要开发对以可预测的方式释放治疗有效载荷的能力具有更高程度控制的先进系统。目前的研究提出了在其表面上具有“开-关”孔帽的杂化无机多孔纳米颗粒的制造，所述杂化无机多孔纳米颗粒由热和pH响应性重组聚合物制成。在体温和血流的中性pH下，聚合物将在颗粒孔上塌陷，防止药物释放。在pH降低的环境中（如肿瘤内和周围），聚合物将溶解，允许药物释放。更广泛的影响：这些混合纳米结构一方面提供了坚固的无机核的好处，它们的尺寸和孔隙率在生物环境中不会改变，另一方面提供了柔性表面接枝聚合物，允许控制药物释放。纳米平台可以广泛应用于递送、传感、分离、诊断和使用智能材料的其他领域。该项目的教育部分将促进新一代学生和科学家的培训，他们将能够在基础科学和应用科学的界面上工作，以设计用于生物医学应用的新型纳米结构。

Proposal No.: 0608906Title: NIRT: Stimuli-responsive hybrid nanoparticles for controlled chemical deliveryPI: Hamid GhandehariInstitution: University of Maryland at BaltimoreABSTRACTIntellectual Merit:This proposal was received in response to Nanoscale Science and Engineering initiative, NSF 05-610, category NIRT. The objective of this research is to construct hybrid stimuli-responsive nanoparticles for controlled delivery of bioactive agents. The approach is to: i) fabricate porous nanoparticles made of gold, silica or composites thereof grafted with genetically engineered stimuli-sensitive polymers and ii) evaluate biomolecule loading, diffusion, and release from the nanoconstructs as a function of environmental conditions (pH, temperature).Controlled drug delivery systems traditionally use chemically synthesized polymer-based materials. Control over polymer structure is a major challenge, which affects their ability to carry and release drugs in the body. There is a clear need to develop advanced systems with a higher degree of control over their ability to release the therapeutic payload in a predictable manner. The current research proposes the fabrication of hybrid inorganic porous nanoparticles with "on-off" pore caps on their surface made of thermal and pH - responsive recombinant polymers. At body temperature and neutral pH of the blood stream the polymers will be collapsed over the particle pores preventing drug release. In the decreased pH environment (such as that in and around a tumor) the polymers will be solubilized, allowing drug release. Broader Impacts:These hybrid nanostructures provide the benefit of robust inorganic cores on one hand where their size and porosity do not change in biological environments, and the flexible surface grafted polymers on the other allowing controlled drug release. The nanoplatforms can be broadly applied in delivery, sensing, separation, diagnostics and other areas where smart materials are utilized. The educational component of this project will facilitate training of new generations of students and scientists who will be able to work at the interface of basic and applied sciences for the design of novel nanoconstructs for use in biomedical applications.