NIRT: Stimuli-responsive hybrid nanoparticles for controlled chemical delivery

提案编号：0608906标题：NIRT：用于受控化学品输送的刺激响应型混合纳米颗粒PI：哈米德·加德哈里研究所：马里兰大学巴尔的摩分校情报优点：本提案是对NSF 05-610类纳米科学与工程倡议的响应而收到的。本研究的目的是构建复合刺激响应型纳米颗粒，用于生物活性物质的控制输送。方法是：i)制备由金、二氧化硅或其与基因工程刺激敏感聚合物的复合材料制成的多孔纳米颗粒，以及ii)评估生物分子的负载、扩散和从纳米结构中释放作为环境条件(pH、温度)的函数。受控给药系统传统上使用化学合成的聚合物基材料。对聚合物结构的控制是一个重大挑战，这影响了它们在体内携带和释放药物的能力。显然需要开发先进的系统，对其以可预测的方式释放治疗有效载荷的能力进行更高程度的控制。目前的研究提出了用热敏和pH响应型重组聚合物制备表面带有“开-关”孔帽的杂化无机多孔纳米颗粒。在体温和血流的中性pH条件下，聚合物会坍塌在颗粒孔隙上，阻止药物释放。在pH降低的环境中(如肿瘤内和肿瘤周围)，聚合物将被溶解，从而允许药物释放。更广泛的影响：这些混合纳米结构一方面提供了坚固的无机核心的好处，其中它们的尺寸和孔隙率在生物环境中不会改变，另一方面提供了灵活的表面接枝聚合物，允许受控药物释放。纳米平台可广泛应用于输送、传感、分离、诊断等利用智能材料的领域。该项目的教育部分将促进新一代学生和科学家的培训，他们将能够在基础科学和应用科学的交界处工作，设计用于生物医学应用的新型纳米结构。

Proposal No.: 0608906Title: NIRT: Stimuli-responsive hybrid nanoparticles for controlled chemical deliveryPI: Hamid GhandehariInstitution: University of Maryland at BaltimoreABSTRACTIntellectual Merit:This proposal was received in response to Nanoscale Science and Engineering initiative, NSF 05-610, category NIRT. The objective of this research is to construct hybrid stimuli-responsive nanoparticles for controlled delivery of bioactive agents. The approach is to: i) fabricate porous nanoparticles made of gold, silica or composites thereof grafted with genetically engineered stimuli-sensitive polymers and ii) evaluate biomolecule loading, diffusion, and release from the nanoconstructs as a function of environmental conditions (pH, temperature).Controlled drug delivery systems traditionally use chemically synthesized polymer-based materials. Control over polymer structure is a major challenge, which affects their ability to carry and release drugs in the body. There is a clear need to develop advanced systems with a higher degree of control over their ability to release the therapeutic payload in a predictable manner. The current research proposes the fabrication of hybrid inorganic porous nanoparticles with "on-off" pore caps on their surface made of thermal and pH - responsive recombinant polymers. At body temperature and neutral pH of the blood stream the polymers will be collapsed over the particle pores preventing drug release. In the decreased pH environment (such as that in and around a tumor) the polymers will be solubilized, allowing drug release. Broader Impacts:These hybrid nanostructures provide the benefit of robust inorganic cores on one hand where their size and porosity do not change in biological environments, and the flexible surface grafted polymers on the other allowing controlled drug release. The nanoplatforms can be broadly applied in delivery, sensing, separation, diagnostics and other areas where smart materials are utilized. The educational component of this project will facilitate training of new generations of students and scientists who will be able to work at the interface of basic and applied sciences for the design of novel nanoconstructs for use in biomedical applications.