Acquisition of a Cyber-enabled Regional 400 MHz Solid-State NMR Spectrometer

采购网络支持的区域 400 MHz 固态核磁共振波谱仪

• 批准号: 0840515
• 负责人: Joseph Heppert
• 金额: $ 57.78万
• 依托单位: University of Kansas Center for Research Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2013-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0840515&HistoricalAwards=false
• 关键词: Acquisition; Cyber; enabled; Regional; 400

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). With support from the Chemistry Research Instrumentation and Facilities: Multiuser program (CRIF:MU), the Chemistry Department at the University of Kansas will acquire a 400 MHz solid state nuclear magnetic resonance (ssNMR) spectrometer. The acquisition will advance a range of research projects, including: 1) identifying and quantifying the various functional groups that reside within the soil, including: carbonyl, phenolic OH, alcohols, aldehydes, amines, ester links, carboxyl groups as well as aromatic rings, 2) quantifying the dynamics and structure of biological macromolecules to determine their role in cellular function and biomolecular recognition, 3) improving the sensitivity of ssNMR to study pharmaceutical solids, 4) establishing the fibrilar structure of the full-length beta2-microglobulin protein in dialysis-related amyloid towards understanding the role amyloid fibrils play in disease, 5) investigating metal binding by teichoic acid, and 6) obtaining mechanistic information concerning enzyme expansion from study of protein backbone dynamics at sites distant from the binding site. Solid-state NMR spectroscopy is a very powerful analytical technique for the analysis of solids in research fields as diverse as chemistry, materials science, food and agricultural products, pharmaceuticals, biology, soil science, geology, and engineering. The spectra enable researchers to identify and characterize substances. They provide information on the arrangement and connectivity of atoms in molecules and materials i.e. their structures by detecting transitions between energy levels arising from the nuclear spin properties of atoms. This acquisition will promote education and the dissemination of information by training graduate students and postdoctoral associates in performing solid-state NMR experiments and incorporating ssNMR spectroscopy into the undergraduate curriculum. The spectrometer will used by researchers at the University of Missouri- Kansas City, Oklahoma State University, and the University of Oklahoma. It will be open to other researchers throughout the states of Kansas, Missouri, and Oklahoma. The instrument will be cyber enabled to enhance this wide use and allow users to monitor the course of their experiments remotely.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。在化学研究仪器和设施：多用户计划（CRIF：MU）的支持下，堪萨斯大学化学系将获得一台400 MHz固态核磁共振（ssNMR）光谱仪。此次收购将推进一系列研究项目，包括：1）识别和量化土壤中存在的各种官能团，包括：羰基、酚OH、醇、醛、胺、酯键、羧基以及芳环，2）量化生物大分子的动力学和结构以确定它们在细胞功能和生物分子识别中的作用，3）提高ssNMR研究药物固体的灵敏度，4）建立透析相关淀粉样蛋白中全长β 2-微球蛋白的纤维结构，以了解淀粉样蛋白纤维在疾病中的作用，5）研究磷壁酸的金属结合，和6）从远离结合位点的位点处的蛋白质骨架动力学的研究中获得关于酶扩增的机理信息。固态NMR光谱是一种非常强大的分析技术，可用于化学、材料科学、食品和农产品、制药、生物学、土壤科学、地质学和工程学等研究领域的固体分析。光谱使研究人员能够识别和表征物质。它们通过检测原子核自旋性质引起的能级之间的跃迁，提供有关分子和材料中原子排列和连接性的信息，即它们的结构。此次收购将通过培训研究生和博士后同事进行固态NMR实验并将ssNMR光谱学纳入本科课程来促进教育和信息传播。该光谱仪将由密苏里州-堪萨斯城大学、俄克拉荷马州州立大学和俄克拉荷马州大学的研究人员使用。它将向整个堪萨斯、密苏里州和俄克拉荷马州的其他研究人员开放。该仪器将通过网络启用，以加强这种广泛的使用，并允许用户远程监测其实验过程。