Acquisition of a Cyber-enabled Regional 400 MHz Solid-State NMR Spectrometer

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。在化学研究仪器和设施：多用户计划（CRIF:MU）的支持下，堪萨斯大学化学系将获得一台400 MHz固态核磁共振（ssNMR）光谱仪。此次收购将推进一系列研究项目，包括：1)识别和量化土壤中的各种功能群，包括：羰基、酚羟基、醇类、醛类、胺类、酯连接、羧基以及芳香环；2)量化生物大分子的动力学和结构，以确定其在细胞功能和生物分子识别中的作用；3)提高ssNMR研究药物固体的灵敏度；4)在透析相关淀粉样蛋白中建立全长β -微球蛋白蛋白的原纤维结构，以了解淀粉样蛋白原纤维在疾病中的作用；5)研究铁壁酸与金属的结合；6)从远离结合位点的蛋白质骨干动力学研究中获得酶扩增的机制信息。固体核磁共振波谱是一种非常强大的分析技术，用于分析化学、材料科学、食品和农产品、制药、生物、土壤科学、地质和工程等研究领域的固体。光谱使研究人员能够识别和表征物质。它们提供了分子和材料中原子的排列和连通性的信息，即它们的结构，通过检测原子的核自旋特性引起的能级之间的跃迁。此次收购将通过培训研究生和博士后进行固态核磁共振实验，并将固态核磁共振光谱纳入本科课程，促进教育和信息传播。该光谱仪将由密苏里大学堪萨斯城分校、俄克拉何马州立大学和俄克拉何马大学的研究人员使用。它将对堪萨斯州、密苏里州和俄克拉何马州的其他研究人员开放。该仪器将在网络上启用，以加强这种广泛的使用，并允许用户远程监控他们的实验过程。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). With support from the Chemistry Research Instrumentation and Facilities: Multiuser program (CRIF:MU), the Chemistry Department at the University of Kansas will acquire a 400 MHz solid state nuclear magnetic resonance (ssNMR) spectrometer. The acquisition will advance a range of research projects, including: 1) identifying and quantifying the various functional groups that reside within the soil, including: carbonyl, phenolic OH, alcohols, aldehydes, amines, ester links, carboxyl groups as well as aromatic rings, 2) quantifying the dynamics and structure of biological macromolecules to determine their role in cellular function and biomolecular recognition, 3) improving the sensitivity of ssNMR to study pharmaceutical solids, 4) establishing the fibrilar structure of the full-length beta2-microglobulin protein in dialysis-related amyloid towards understanding the role amyloid fibrils play in disease, 5) investigating metal binding by teichoic acid, and 6) obtaining mechanistic information concerning enzyme expansion from study of protein backbone dynamics at sites distant from the binding site. Solid-state NMR spectroscopy is a very powerful analytical technique for the analysis of solids in research fields as diverse as chemistry, materials science, food and agricultural products, pharmaceuticals, biology, soil science, geology, and engineering. The spectra enable researchers to identify and characterize substances. They provide information on the arrangement and connectivity of atoms in molecules and materials i.e. their structures by detecting transitions between energy levels arising from the nuclear spin properties of atoms. This acquisition will promote education and the dissemination of information by training graduate students and postdoctoral associates in performing solid-state NMR experiments and incorporating ssNMR spectroscopy into the undergraduate curriculum. The spectrometer will used by researchers at the University of Missouri- Kansas City, Oklahoma State University, and the University of Oklahoma. It will be open to other researchers throughout the states of Kansas, Missouri, and Oklahoma. The instrument will be cyber enabled to enhance this wide use and allow users to monitor the course of their experiments remotely.