CAREER: STUDIES OF ANION-RECEPTOR AND CH-ANION BINDING USING TRIAZOLOPHANES

职业：使用三唑啉研究阴离子受体和 C-阴离子结合

• 批准号: 0844441
• 负责人: Amar Flood
• 金额: $ 62.5万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0844441&HistoricalAwards=false
• 关键词: CAREER; STUDIES; ANION; RECEPTOR; CH

The Organic and Macromolecular Chemistry Program supports Professor Amar Flood of Indiana University for the synthesis and characterization of modular anion-binding receptors, called triazolophanes. Surprisingly, these triazolophanes incorporate only weak CH hydrogen bond donors. Therefore, the structural and electronic parameters that enforce strong anion affinities in these receptors will be determined by thermodynamic analyses. As a consequence of these investigations, the strengths of the two types of CH donors will be addressed. The effects of electronics, size and shape, flexibility, charge, axial ligation and dimerization will be evaluated. Secondly, template-directed approaches will be developed to effect more efficient syntheses of the triazolophanes by conducting kinetics studies in a step-wise manner on the individual reaction steps involved in the overall one-pot preparation. The proposed research will answer questions about how triazolophanes bind anions, how strong the C-H H-bonding interactions are, and about the templating effect of anions in macrocyclization.With the support of the Organic Dynamics Program in the Chemistry Division, Dr. Flood is developing inquiry-based learning modules using nanoscience and nanotechnology as a hook for non-science majors at local high schools and at the undergraduate level in order to engage students with science. The PI wants to introduce high school students to real scientific inquiry in the lecture hall versus canned discourse in which individuals can choose their particular level of involvement. He is going to use the chemical technology and the nanoscience involved in producing the iPod to attract students. For the younger people who are interested in playing video games, the PI is going to involve game theory in education. To help with this project, he is collaborating with the Indiana University College of Education to use virtual worlds (Quest Atlantis) and gaming strategies to attract the younger students.

有机和大分子化学计划支持印第安纳大学的Amar洪水泛滥，以合成和表征模块化阴离子结合受体，称为三酚。令人惊讶的是，这些三酚仅融合了弱的CH氢键供体。因此，在这些受体中强大阴离子亲和力的结构和电子参数将由热力学分析确定。由于这些调查，将解决两种类型的CH供体的优势。将评估电子设备，大小和形状，柔韧性，电荷，轴向连接和二聚化的影响。其次，将开发以模板为导向的方法来通过以逐步进行动力学研究来实现三唑泳的更有效合成，以对整体一锅准备的各个反应步骤进行逐步进行动力学研究。拟议的研究将回答有关三唑哲学如何结合阴离子，C-H H键的相互作用的强度以及阴离子在巨大环化中的模板效应的问题。在化学部门在化学动力学部门的支持下，Flood博士正在使用纳米科学和纳米级的nockient and nockient and Science and Science基于询问的研究模​​块，以开发基于询问的学习模块。科学的学生。 PI希望在演讲厅与罐头话语一起介绍高中生进行真正的科学探究，其中个人可以选择其特定的参与水平。他将使用化学技术和纳米科学来生产iPod来吸引学生。对于有兴趣玩电子游戏的年轻人，PI将涉及教育中的游戏理论。为了帮助该项目，他正在与印第安纳大学教育学院合作使用虚拟世界（Quest Atlantis）和游戏策略来吸引年轻学生。