CAREER: STUDIES OF ANION-RECEPTOR AND CH-ANION BINDING USING TRIAZOLOPHANES

职业：使用三唑啉研究阴离子受体和 C-阴离子结合

• 批准号: 0844441
• 负责人: Amar Flood
• 金额: $ 62.5万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0844441&HistoricalAwards=false
• 关键词: CAREER; STUDIES; ANION; RECEPTOR; CH

The Organic and Macromolecular Chemistry Program supports Professor Amar Flood of Indiana University for the synthesis and characterization of modular anion-binding receptors, called triazolophanes. Surprisingly, these triazolophanes incorporate only weak CH hydrogen bond donors. Therefore, the structural and electronic parameters that enforce strong anion affinities in these receptors will be determined by thermodynamic analyses. As a consequence of these investigations, the strengths of the two types of CH donors will be addressed. The effects of electronics, size and shape, flexibility, charge, axial ligation and dimerization will be evaluated. Secondly, template-directed approaches will be developed to effect more efficient syntheses of the triazolophanes by conducting kinetics studies in a step-wise manner on the individual reaction steps involved in the overall one-pot preparation. The proposed research will answer questions about how triazolophanes bind anions, how strong the C-H H-bonding interactions are, and about the templating effect of anions in macrocyclization.With the support of the Organic Dynamics Program in the Chemistry Division, Dr. Flood is developing inquiry-based learning modules using nanoscience and nanotechnology as a hook for non-science majors at local high schools and at the undergraduate level in order to engage students with science. The PI wants to introduce high school students to real scientific inquiry in the lecture hall versus canned discourse in which individuals can choose their particular level of involvement. He is going to use the chemical technology and the nanoscience involved in producing the iPod to attract students. For the younger people who are interested in playing video games, the PI is going to involve game theory in education. To help with this project, he is collaborating with the Indiana University College of Education to use virtual worlds (Quest Atlantis) and gaming strategies to attract the younger students.

有机和大分子化学计划支持印第安纳州大学的Amar Flood教授合成和表征模块化阴离子结合受体，称为三唑啉。令人惊讶的是，这些三唑并吡喃仅掺入弱CH氢键供体。因此，在这些受体中执行强阴离子亲和力的结构和电子参数将通过热力学分析来确定。作为这些调查的结果，这两种类型的CH捐助者的优势将得到解决。将评价电子学、大小和形状、柔性、电荷、轴向结扎和二聚化的影响。其次，将开发模板导向的方法，以实现更有效的合成的三唑啉，通过进行动力学研究，在一个逐步的方式对涉及整体的一锅制备的各个反应步骤。该研究将回答三唑啉如何结合阴离子，C-H氢键相互作用有多强，以及大环化中阴离子的模板效应等问题。在化学部有机动力学计划的支持下，Flood博士正在开发基于探究的学习模块，使用纳米科学和纳米技术作为非生物学的挂钩。在当地高中和本科阶段开设理科专业，以吸引学生学习科学。PI希望在演讲厅向高中生介绍真实的科学探究，而不是个人可以选择其特定参与程度的罐头话语。他打算利用生产iPod所涉及的化学技术和纳米科学来吸引学生。对于那些对玩电子游戏感兴趣的年轻人，PI将在教育中引入博弈论。为了帮助这个项目，他正在与印第安纳州大学教育学院合作，利用虚拟世界（Quest Atlantis）和游戏策略来吸引年轻学生。