CAREER: STUDIES OF ANION-RECEPTOR AND CH-ANION BINDING USING TRIAZOLOPHANES

有机和大分子化学项目支持印第安纳大学的Amar Flood教授合成和表征模块化阴离子结合受体，称为三唑啉。令人惊讶的是，这些三唑啉化合物只结合了弱CH氢键供体。因此，在这些受体中加强强阴离子亲和力的结构和电子参数将通过热力学分析来确定。作为这些调查的结果，将处理两类CH捐助者的优势。电子学、尺寸和形状、柔韧性、电荷、轴向结扎和二聚化的影响将被评估。其次，将开发模板导向的方法，通过对整个单锅制备中涉及的单个反应步骤进行逐步的动力学研究，以实现更有效的三唑啉合成。提出的研究将回答有关三唑啉如何与阴离子结合，C-H -键相互作用有多强，以及阴离子在大环化中的模板效应等问题。在化学部门有机动力学项目的支持下，Flood博士正在开发基于探究的学习模块，将纳米科学和纳米技术作为当地高中和本科非科学专业学生的一个钩子，以吸引学生参与科学。PI希望在课堂上向高中生介绍真正的科学探究，而不是个人可以选择自己特定参与程度的刻板话语。他打算利用化学技术和纳米技术来生产iPod，以吸引学生。对于那些对玩电子游戏感兴趣的年轻人来说，PI将在教育中涉及博弈论。为了帮助这个项目，他正在与印第安纳大学教育学院合作，使用虚拟世界（探索亚特兰蒂斯）和游戏策略来吸引年轻的学生。

The Organic and Macromolecular Chemistry Program supports Professor Amar Flood of Indiana University for the synthesis and characterization of modular anion-binding receptors, called triazolophanes. Surprisingly, these triazolophanes incorporate only weak CH hydrogen bond donors. Therefore, the structural and electronic parameters that enforce strong anion affinities in these receptors will be determined by thermodynamic analyses. As a consequence of these investigations, the strengths of the two types of CH donors will be addressed. The effects of electronics, size and shape, flexibility, charge, axial ligation and dimerization will be evaluated. Secondly, template-directed approaches will be developed to effect more efficient syntheses of the triazolophanes by conducting kinetics studies in a step-wise manner on the individual reaction steps involved in the overall one-pot preparation. The proposed research will answer questions about how triazolophanes bind anions, how strong the C-H H-bonding interactions are, and about the templating effect of anions in macrocyclization.With the support of the Organic Dynamics Program in the Chemistry Division, Dr. Flood is developing inquiry-based learning modules using nanoscience and nanotechnology as a hook for non-science majors at local high schools and at the undergraduate level in order to engage students with science. The PI wants to introduce high school students to real scientific inquiry in the lecture hall versus canned discourse in which individuals can choose their particular level of involvement. He is going to use the chemical technology and the nanoscience involved in producing the iPod to attract students. For the younger people who are interested in playing video games, the PI is going to involve game theory in education. To help with this project, he is collaborating with the Indiana University College of Education to use virtual worlds (Quest Atlantis) and gaming strategies to attract the younger students.