Anion-driven recognition and assemblies of shape-persistent cyanostar macrocycles

阴离子驱动的形状持久氰星大环化合物的识别和组装

基本信息

批准号：
1709909
负责人：
Amar Flood
金额：
$ 49.35万
依托单位：
Indiana University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2021-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1709909&HistoricalAwards=false
关键词：
Anion driven recognition assemblies shape

项目摘要

Molecular recognition and self-assembly are powerful approaches to fabricate materials of complex architecture and to assemble functional systems for applications in environmental remediation, drug delivery, and biomedical sensing. Prof. Flood at Indiana University studies how molecules interact with each other in order to increase our fundamental understanding of the factors governing molecular recognition and self-assembly. This project also provides student training, usage of 3D printed molecules to enhance scientific understanding, and opportunities for technology transfer. With the support from the Macromolecular, Supramolecular and Nanochemistry Program of the NSF Division of Chemistry, Professor Flood conducts research to understand the factors controlling the anion-driven recognition and assemblies of shape-persistent macrocycles. There are three specific aims in this project. Aim 1 focuses on examining the factors that affect the formation of complexes between hydroxyanions and cyanostar macrocycles in solution. Aim 2 seeks to establish the correlation between the anion-driven binding and template-directed synthesis and create prototypes of molecular switches. Aim 3 strives to develop the rules governing the directed assembly of cyanostars into dodecahedra enabling their high-fidelity preparation.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

分子识别和自组装是制造复杂建筑材料并组装功能系统以在环境补救，药物输送和生物医学感应中应用功能系统的强大方法。印第安纳大学研究教授研究分子如何相互相互作用，以增加我们对控制分子识别和自组装因素的基本理解。该项目还提供学生培训，使用3D印刷分子以增强科学理解以及技术转移的机会。在NSF化学司的大分子，超分子和纳米化学计划的支持下，洪水教授进行了研究，以了解控制阴离子驱动的识别和组装形状持久性大环的因素。该项目有三个具体的目标。 AIM 1专注于检查影响溶液中羟基和氰层大环之间复合物形成的因素。 AIM 2试图在阴离子驱动的结合和模板定向合成之间建立相关性，并创建分子开关的原型。 AIM 3努力制定管理Cyanostars的指示组装的规则，以实现其高保真准备。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛的影响审查标准通过评估来进行评估的。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Zero-Overlap Fluorophores for Fluorescent Studies at Any Concentration

DOI：
10.1021/jacs.0c02450
发表时间：
2020-07-15
期刊：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
影响因子：
15
作者：
Dhara, Ayan;Sadhukhan, Tumpa;Flood, Amar H.
通讯作者：
Flood, Amar H.

Cages Driven Away from Equilibrium Binding by Electric Fields

电场驱使笼子脱离平衡结合

DOI：
10.1016/j.chempr.2019.04.020
发表时间：
2019
期刊：
Chem
影响因子：
23.5
作者：
Dhara, Ayan;Flood, Amar H.
通讯作者：
Flood, Amar H.

Inchworm movement of two rings switching onto a thread by biased Brownian diffusion represent a three-body problem

DOI：
10.1073/pnas.1719539115
发表时间：
2018-09-18
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子：
11.1
作者：
Benson, Christopher R.;Maffeo, Christopher;Flood, Amar H.
通讯作者：
Flood, Amar H.

Anion-Selective Electrodes Based On a CH-Hydrogen Bonding Bis-macrocyclic Ionophore with a Clamshell Architecture