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Anion-driven recognition and assemblies of shape-persistent cyanostar macrocycles

阴离子驱动的形状持久氰星大环化合物的识别和组装

基本信息

批准号：
1709909
负责人：
Amar Flood
金额：
$ 49.35万
依托单位：
Indiana University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2021-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1709909&HistoricalAwards=false
关键词：
Anion driven recognition assemblies shape

项目摘要

Molecular recognition and self-assembly are powerful approaches to fabricate materials of complex architecture and to assemble functional systems for applications in environmental remediation, drug delivery, and biomedical sensing. Prof. Flood at Indiana University studies how molecules interact with each other in order to increase our fundamental understanding of the factors governing molecular recognition and self-assembly. This project also provides student training, usage of 3D printed molecules to enhance scientific understanding, and opportunities for technology transfer. With the support from the Macromolecular, Supramolecular and Nanochemistry Program of the NSF Division of Chemistry, Professor Flood conducts research to understand the factors controlling the anion-driven recognition and assemblies of shape-persistent macrocycles. There are three specific aims in this project. Aim 1 focuses on examining the factors that affect the formation of complexes between hydroxyanions and cyanostar macrocycles in solution. Aim 2 seeks to establish the correlation between the anion-driven binding and template-directed synthesis and create prototypes of molecular switches. Aim 3 strives to develop the rules governing the directed assembly of cyanostars into dodecahedra enabling their high-fidelity preparation.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

分子识别和自组装是制备复杂结构材料和组装功能体系的有效途径，可用于环境修复、药物释放和生物医学传感。印第安纳大学的Flood教授研究分子之间的相互作用，以增加我们对分子识别和自组装因素的基本理解。该项目还提供学生培训、3D打印分子的使用以增进科学理解，以及技术转让的机会。在美国国家科学基金会化学部大分子、超分子和纳米化学项目的支持下，Flood教授进行了研究，以了解控制阴离子驱动的形状持久大环识别和组装的因素。这个项目有三个具体目标。目的1重点考察溶液中羟基阴离子与氰化星大环形成络合物的影响因素。目的2试图建立阴离子驱动的结合和模板指导的合成之间的联系，并创造分子开关的原型。AIM 3致力于制定将蓝星定向组装成十二面体的规则，使它们能够进行高保真的准备。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Zero-Overlap Fluorophores for Fluorescent Studies at Any Concentration

DOI：
10.1021/jacs.0c02450
发表时间：
2020-07-15
期刊：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
影响因子：
15
作者：
Dhara, Ayan;Sadhukhan, Tumpa;Flood, Amar H.
通讯作者：
Flood, Amar H.

Cages Driven Away from Equilibrium Binding by Electric Fields

电场驱使笼子脱离平衡结合

DOI：
10.1016/j.chempr.2019.04.020
发表时间：
2019
期刊：
Chem
影响因子：
23.5
作者：
Dhara, Ayan;Flood, Amar H.
通讯作者：
Flood, Amar H.

Inchworm movement of two rings switching onto a thread by biased Brownian diffusion represent a three-body problem

DOI：
10.1073/pnas.1719539115
发表时间：
2018-09-18
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子：
11.1
作者：
Benson, Christopher R.;Maffeo, Christopher;Flood, Amar H.
通讯作者：
Flood, Amar H.

Anion-Selective Electrodes Based On a CH-Hydrogen Bonding Bis-macrocyclic Ionophore with a Clamshell Architecture