The Development of a Collaborative Research Plan for NIST and the Semiconductor Industry for Nanoelectronics Research in the Bio-Sciences

目标：将制定一项研究计划，通过将半导体行业的技术能力应用于迫切的生物科学需求，直接将半导体行业与NIST结合起来，以支持生物科学研究。这将通过两个步骤完成，即SRC将向大学生物科学研究人员发放补助金，以制定五年研究计划，他们将在咨询的基础上得到一名领先的大学生物电子学研究人员的帮助。其次，当计划草案完成后，它将提交给来自NIST、NIH、NSF、半导体行业、SRC和大学的人员圆桌会议，以供审查和评论。这次圆桌会议的反馈将被整合到最终的研究计划中，然后提交给NIST和半导体行业，以供可能的实施。完成的计划将广泛提供给感兴趣的机构和基金会。智力上的优点：这两个领域的能力的合并为改善人类的生活质量提供了令人兴奋的机会。以下内容对于拟议的研究并不是说明性的或完整的，但例如，我们相信可以开发新的电子技术来进行快速DNA测序、识别和量化蛋白质、检测毒素和分子质谱学。作为一个具体的例子，纳米孔可能应用于快速DNA测序、蛋白质变性检测、炭疽病检测、了解细胞对蛋白质的反应，以及可能用于系统生物学和未来医学应用的全细胞分析。拟议的规划流程将定义潜在的技术应用领域，确定具体的技术需求及其相关的时间范围。更广泛的影响：如果拟议计划确定的研究成功进行，如果其实施产生了解决已确定需求的计划，则可能首先在研究社区感受到影响。与研究思路和概念相称的是培养纳米电子和生物科学跨学科领域的优秀研究生。在下游，我们将更好地了解生物系统，这些系统可以转化为用于医疗器械、测试和治疗的改进方法和工具。最后，这项研究的大规模应用可以促进工业的增长，从而为国家的经济增长提供支持。

Objective: A research plan will be developed to directly couple the semiconductor industry and NIST in the support of bio-sciences research through the application of the industries' technological capabilities to pressing bio-science needs. This will be accomplished via a two-step process, i.e., a grant will be issued by SRC to university researchers in bio-sciences to develop a five-year research plan and they will be aided by a leading university researcher in bio-electronics on a consulting basis. Secondly, when the draft plan is complete, it will be presented at a roundtable meeting of personnel from NIST, NIH, NSF, the semiconductor industry, SRC, and universities for review and comment. The feedback from this roundtable will be integrated into the final research plan that will then be presented to NIST and to the semiconductor industry for possible implementation. The completed plan will be made widely available to interested agencies and foundations.Intellectual Merit: The merger of the capabilities of these two fields offers exciting opportunities to improve the quality of life for humankind. The following is not intended to be prescriptive nor complete for the proposed study but, for example, we believe that new electronic technologies can be developed for rapid DNA sequencing, to identify and quantify proteins, to detect toxins, and for molecular mass spectroscopy. As a specific example, nano-pores may have application for rapid DNA sequencing, for protein denaturation detection, for anthrax detection, for understanding how cells respond to proteins, and possibly for total cell analysis for system biology and for future medical applications. The proposed planning process will define potential technology application areas, identify specific technology needs and their associated time horizons.Broader Impact: The impact of the successful conduct of the research identified by the proposed plan would likely first be felt in the research community if its implementation resulted in programs to address needs that are identified. Commensurate with the research ideas and conceptsthat would result is the training of outstanding graduate students in the cross-disciplinary field of nano-electronics and bio-sciences. Further downstream, we there would result better understanding of biological systems that could be translated into improved methods and tools used in medical instrumentation, testing and therapy. Finally, large scale applications of this research could promote the growth of industry and thereby provide for economic growth for the nation.