The Development of a Collaborative Research Plan for NIST and the Semiconductor Industry for Nanoelectronics Research in the Bio-Sciences

目的：将制定一项研究计划，通过将半导体行业的技术能力应用于紧迫的生物科学需求，将半导体行业和NIST直接结合起来，支持生物科学研究。这将通过两步过程来实现，即，研究中心将向大学生物科学研究人员发放一笔补助金，以制定一项五年研究计划，并将由一名大学生物电子学方面的主要研究人员提供咨询服务。第二，当计划草案完成后，将提交给NIST、NIH、NSF、半导体行业、SRC和大学的人员参加的圆桌会议，以供审查和评论。本次圆桌会议的反馈将被整合到最终的研究计划中，然后提交给NIST和半导体行业，以供可能的实施。完成后的计划将广泛提供给感兴趣的机构和基金会。智力优势：这两个领域的能力的结合为改善人类的生活质量提供了令人兴奋的机会。以下内容并不是对拟议研究的规定性或完整性，但我们认为，例如，可以开发新的电子技术用于快速DNA测序，识别和定量蛋白质，检测毒素和分子质谱。作为一个具体的例子，纳米孔可以应用于快速DNA测序，用于蛋白质变性检测，用于炭疽检测，用于理解细胞如何响应蛋白质，以及可能用于系统生物学和未来医学应用的总细胞分析。拟议的规划过程将界定潜在的技术应用领域，确定具体的技术需求及其相关的时间范围。更广泛的影响：如果拟议的计划的实施导致了解决所确定需求的计划，那么成功进行拟议的计划所确定的研究的影响可能首先会在研究界感受到。与研究思想和概念相适应，将导致在纳米电子学和生物科学的跨学科领域培养优秀的研究生。在下游，我们将更好地理解生物系统，这些系统可以转化为用于医疗仪器，测试和治疗的改进方法和工具。最后，这项研究的大规模应用可以促进工业的发展，从而为国家的经济增长提供支持。

Objective: A research plan will be developed to directly couple the semiconductor industry and NIST in the support of bio-sciences research through the application of the industries' technological capabilities to pressing bio-science needs. This will be accomplished via a two-step process, i.e., a grant will be issued by SRC to university researchers in bio-sciences to develop a five-year research plan and they will be aided by a leading university researcher in bio-electronics on a consulting basis. Secondly, when the draft plan is complete, it will be presented at a roundtable meeting of personnel from NIST, NIH, NSF, the semiconductor industry, SRC, and universities for review and comment. The feedback from this roundtable will be integrated into the final research plan that will then be presented to NIST and to the semiconductor industry for possible implementation. The completed plan will be made widely available to interested agencies and foundations.Intellectual Merit: The merger of the capabilities of these two fields offers exciting opportunities to improve the quality of life for humankind. The following is not intended to be prescriptive nor complete for the proposed study but, for example, we believe that new electronic technologies can be developed for rapid DNA sequencing, to identify and quantify proteins, to detect toxins, and for molecular mass spectroscopy. As a specific example, nano-pores may have application for rapid DNA sequencing, for protein denaturation detection, for anthrax detection, for understanding how cells respond to proteins, and possibly for total cell analysis for system biology and for future medical applications. The proposed planning process will define potential technology application areas, identify specific technology needs and their associated time horizons.Broader Impact: The impact of the successful conduct of the research identified by the proposed plan would likely first be felt in the research community if its implementation resulted in programs to address needs that are identified. Commensurate with the research ideas and conceptsthat would result is the training of outstanding graduate students in the cross-disciplinary field of nano-electronics and bio-sciences. Further downstream, we there would result better understanding of biological systems that could be translated into improved methods and tools used in medical instrumentation, testing and therapy. Finally, large scale applications of this research could promote the growth of industry and thereby provide for economic growth for the nation.