CAREER: Spatially Controlled Cellular Behavior in 3D Hydrogels: An Integrated Research, Teaching, and Outreach Approach
职业:3D 水凝胶中空间控制的细胞行为:一种综合研究、教学和推广方法
基本信息
- 批准号:0845472
- 负责人:
- 金额:$ 40万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-07-01 至 2014-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
0845472BurdickThe overall objective of this project is to design and develop novel dynamic hydrogels that can be used to control adult mesenchymal stem cell behavior in 3-dimensions, as well as to integrate education into the research plan at the university, local, and international levels. The premise of the work is that further fundamental knowledge and subsequent control of the cell-environment interactions, gained through the development of novel biomaterials, will help advance the field. With this in mind, the governing hypothesis of the proposed work is that hydrogels with spatially controlled properties can be used to direct and define cellular spreading, migration, and phenotypes in 3-dimensions, towards the engineering of complex tissues. The objectives of the research plan are: (1) to synthesize novel multifunctional macromers that form networks with spatially controlled properties using sequential crosslinking procedures, (2) to utilize the synthesized hydrogels to control the spreading and migration of mesenchymal stem cells and develop structure/outcome relationships, and (3) to assess control over cellular differentiation in hydrogels through spatially controlled crosslinking density. The proposed research is multidisciplinary and covers many fields from polymer science to cellular biology. Limitations in available materials may have stalled significant advances in the fields of mesenchymal stem cell biology and tissue regeneration, and thus this work presents an intellectual advance in these areas. The proposed educational activities are integrated within this research and include education to graduate students and undergraduate students in the laboratory and classroom, outreach to a local high school, and international outreach to a university in Africa. The specific components include: (1) continued involvement of students, emphasizing women and minority students, in the principal investigator's laboratory and integration of a laboratory component for "hands-on" learning into a course on Biomaterials that is taught to upper-level undergraduate and graduate students; (2) outreach to students in Philadelphia schools through the development of a course on 'Materials in the World' that gives high school students exposure to material science and biomaterials to encourage careers in these fields; and (3) travel to Ghana, Africa to educate students in the area of biomedical engineering, a topic that is not encompassed into any current curriculum, and invitations to students from Africa to join the principal investigator's laboratory at Penn during the summer months.
0845472 Burdick该项目的总体目标是设计和开发新型动态水凝胶,可用于控制成人间充质干细胞的三维行为,以及将教育纳入大学,地方和国际层面的研究计划。 这项工作的前提是,通过开发新型生物材料获得的细胞-环境相互作用的进一步基础知识和后续控制将有助于推进该领域。 考虑到这一点,所提出的工作的主要假设是,具有空间控制特性的水凝胶可用于指导和定义细胞的扩散,迁移和表型在3维,对复杂组织的工程。 该研究计划的目标是:(1)合成新型多功能大分子单体,使用顺序交联程序形成具有空间控制特性的网络,(2)利用合成的水凝胶控制间充质干细胞的扩散和迁移,并开发结构/结果关系,以及(3)通过空间控制交联密度评估对水凝胶中细胞分化的控制。 拟议的研究是多学科的,涵盖了从聚合物科学到细胞生物学的许多领域。可用材料的局限性可能阻碍了间充质干细胞生物学和组织再生领域的重大进展,因此这项工作在这些领域取得了智力进步。 拟议的教育活动已纳入这项研究,包括在实验室和教室对研究生和本科生进行教育,对当地一所高中进行外联,以及对非洲一所大学进行国际外联。 具体组成部分包括:(1)继续让学生,特别是妇女和少数民族学生参与主要研究员的实验室,并将“动手”学习的实验室部分纳入向高年级本科生和研究生教授的生物材料课程;(二)通过开发一门关于“世界材料”的课程,向费城学校的学生提供接触材料科学和生物材料,以鼓励这些领域的职业发展;以及(3)前往非洲加纳,对学生进行生物医学工程领域的教育,该主题未纳入任何当前课程,并邀请非洲学生加入宾夕法尼亚大学首席研究员实验室在夏季的几个月里。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Jason Burdick其他文献
Jason Burdick的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Jason Burdick', 18)}}的其他基金
NSF/DMR-BSF: Ultra-Tough Double-Network Hydrogels for Cartilage Repair
NSF/DMR-BSF:用于软骨修复的超坚韧双网络水凝胶
- 批准号:
1610525 - 财政年份:2016
- 资助金额:
$ 40万 - 项目类别:
Standard Grant
2014 Signal Transduction by Engineered ECM GRC/GRS to be held on July 5-11, 2014 in Waltham, Massachusetts
2014 年工程 ECM GRC/GRS 信号传导大会将于 2014 年 7 月 5 日至 11 日在马萨诸塞州沃尔瑟姆举行
- 批准号:
1351472 - 财政年份:2014
- 资助金额:
$ 40万 - 项目类别:
Standard Grant
Symposium on Engineering Biomaterials for Regenerative Medicine
再生医学工程生物材料研讨会
- 批准号:
0958202 - 财政年份:2009
- 资助金额:
$ 40万 - 项目类别:
Standard Grant
相似海外基金
Chemically Engineered Quantum Materials: Encapsulation for Spatially Controlled Spins as a Quantum Sensor
化学工程量子材料:作为量子传感器的空间控制自旋封装
- 批准号:
EP/W027542/1 - 财政年份:2022
- 资助金额:
$ 40万 - 项目类别:
Fellowship
Mechanisms and consequences of spatially controlled G protein-coupled receptor signaling
空间控制的 G 蛋白偶联受体信号传导的机制和后果
- 批准号:
463586 - 财政年份:2022
- 资助金额:
$ 40万 - 项目类别:
Operating Grants
Modulating 3D Cellular Connectivity Via Spatially-Controlled Programmable Bonding
通过空间控制的可编程绑定调节 3D 蜂窝连接
- 批准号:
10195452 - 财政年份:2021
- 资助金额:
$ 40万 - 项目类别:
Investigation of Synthetic DNA-based Viral Particles for Spatially Controlled Antigen Presentation
基于 DNA 的合成病毒颗粒空间控制抗原呈递的研究
- 批准号:
10253355 - 财政年份:2021
- 资助金额:
$ 40万 - 项目类别:
Investigation of Synthetic DNA-based Viral Particles for Spatially Controlled Antigen Presentation
基于 DNA 的合成病毒颗粒空间控制抗原呈递的研究
- 批准号:
10662377 - 财政年份:2021
- 资助金额:
$ 40万 - 项目类别:
Modulating 3D Cellular Connectivity Via Spatially-Controlled Programmable Bonding
通过空间控制的可编程绑定调节 3D 蜂窝连接
- 批准号:
10471175 - 财政年份:2021
- 资助金额:
$ 40万 - 项目类别:
Investigation of Synthetic DNA-based Viral Particles for Spatially Controlled Antigen Presentation
基于 DNA 的合成病毒颗粒空间控制抗原呈递的研究
- 批准号:
10460559 - 财政年份:2021
- 资助金额:
$ 40万 - 项目类别:
Strategy for spatially-controlled tissue regeneration
空间控制的组织再生策略
- 批准号:
19KK0278 - 财政年份:2019
- 资助金额:
$ 40万 - 项目类别:
Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
Tunable Block Copolymer Templates for Spatially Controlled Immobilization of Molecular Catalysts (A02+)
用于分子催化剂空间控制固定化的可调嵌段共聚物模板 (A02)
- 批准号:
406655856 - 财政年份:2018
- 资助金额:
$ 40万 - 项目类别:
Collaborative Research Centres
Controlled neuronal firing in vivo using two photon spatially shaped optogenetics
使用两个光子空间形状光遗传学控制体内神经元放电
- 批准号:
9770567 - 财政年份:2017
- 资助金额:
$ 40万 - 项目类别: