CAREER: Computing with Things Small, Wet, and Random - Design Automation for Digital Computation with Nanoscale Technologies and Biological Processes

职业：利用小型、潮湿和随机的事物进行计算 - 利用纳米级技术和生物过程进行数字计算的设计自动化

• 批准号: 0845650
• 负责人: Marc Riedel
• 金额: $ 50万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0845650&HistoricalAwards=false
• 关键词: CAREER; Computing; Things; Small; Wet

"This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5)."This project strives for novel and transformative approaches to design automation guided by physical views of computation. A broad theme is the application of expertise from an established field, digital circuit design, to new fields, such as nanotechnology and synthetic biology. A specific theme that cuts across these domains is constructing and deconstructing probabilistic behavior. In the biological realm, the project will develop techniques for synthesizing biochemical systems that produce proteins according to specified probability distributions. This will provide robustness and flexibility ? akin to hedging with a portfolio of investments ? for applications in biochemical sensing and drug delivery. In the engineering realm, the project will develop techniques for designing digital circuits that process zeros and ones probabilistically. This will mitigate against the noise and glitches that occur as circuit components are scaled down in size to nanometers. The circuit design community has unique expertise that can be brought to bear on the challenging design problems in synthetic biology. Applications in biology, in turn, offer a wealth of problems in algorithmic development. With its cross-disciplinary emphasis, this project will bring new perspectives to both fields. An important goal of the project is to communicate the goals and the impetus for interdisciplinary research to a wide audience. A new graduate-level course will be developed, titled "Circuits, Computation, and Biology". In parallel, a book with the same title will be written, to be published by Pan Stanford Publishing. Also public seminars will be given through the Café Scientifique series hosted by the Bell Museum of Natural History in Minneapolis.

“该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。“这个项目致力于通过计算的物理视图来指导设计自动化的新颖和变革性方法。一个广泛的主题是从一个既定的领域，数字电路设计，到新的领域，如纳米技术和合成生物学的专业知识的应用。贯穿这些领域的一个特定主题是构建和解构概率行为。在生物领域，该项目将开发合成生化系统的技术，这些系统根据特定的概率分布产生蛋白质。这将提供鲁棒性和灵活性？类似于用投资组合对冲？用于生物化学传感和药物输送。 在工程领域，该项目将开发设计概率处理0和1的数字电路的技术。这将减轻电路元件尺寸缩小到纳米时出现的噪声和毛刺。电路设计社区拥有独特的专业知识，可以用来解决合成生物学中具有挑战性的设计问题。 反过来，生物学中的应用也为算法开发带来了大量问题。 随着其跨学科的重点，这个项目将带来新的视角，这两个领域。 该项目的一个重要目标是向广大受众传达跨学科研究的目标和动力。 将开发一个新的研究生课程，名为“电路，计算和生物学”。与此同时，将编写一本同名的书，由潘斯坦福大学出版社出版。 此外，还将通过明尼阿波利斯贝尔自然历史博物馆主办的科学咖啡馆系列举办公开研讨会。