RUI: Radical Reactions of Transition Metal-Arene Complexes

RUI：过渡金属芳烃配合物的自由基反应

• 批准号: 0848126
• 负责人: Jeffrey Byers
• 金额: $ 22.5万
• 依托单位: Middlebury College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848126&HistoricalAwards=false
• 关键词: RUI; Radical; Reactions; Transition; Metal

This project will continue work on the development of methods for the formation of C-C bonds using previously undiscovered radical processes. More specifically, the project will study reactions at the interface of two important subdisciplines of organic chemistry, radical-based organic synthesis and transition metal-arene complexes. While transition metals have been used extensively to modify the ionic reactivity of bound organic molecules, very little study has been made of the radical reactions of such systems. This project will address this shortcoming in the chemical literature through the systematic study of a series of transition metal complexes to determine their utility in radical processes.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Jeffrey Byers and six undergraduate summer research assistants in the Department of Chemistry and Biochemistry at Middlebury College. Since both transition metal-promoted processes and radical processes are of significant importance to the chemical industry, this work could open up new avenues for the efficient generation of complex molecules of broad applicability and importance. The possible applications of this methodology include any of the disciplines related to the petrochemical industry, including such diverse fields as pharmaceuticals, agricultural chemicals, and materials science.

该项目将继续致力于开发使用以前未发现的自由基过程形成C-C键的方法。 更具体地说，该项目将研究有机化学两个重要分支学科的界面反应，即基于自由基的有机合成和过渡金属-芳烃络合物。 虽然过渡金属已被广泛用于改变结合的有机分子的离子反应性，很少有研究已经作出了这样的系统的自由基反应。 该项目将通过一系列过渡金属配合物的系统研究来解决化学文献中的这一缺陷，以确定它们在自由基过程中的效用。有了这个奖项，有机和大分子化学计划将支持米德尔伯里学院化学和生物化学系的Jeffrey Byers教授和六名本科生暑期研究助理的研究。 由于过渡金属促进的过程和自由基过程对化学工业具有重要意义，因此这项工作可以为有效产生具有广泛适用性和重要性的复杂分子开辟新的途径。 这种方法的可能应用包括与石化工业相关的任何学科，包括制药，农业化学品和材料科学等不同领域。