MRI: Acquisition of an LC/MS system for Middlebury College

MRI：为米德尔伯里学院采购 LC/MS 系统

• 批准号: 0520708
• 负责人: Jeffrey Byers
• 金额: $ 19.9万
• 依托单位: Middlebury College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0520708&HistoricalAwards=false
• 关键词: MRI; Acquisition; LC; MS; system

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry and Biochemistry at Middlebury College will acquire a liquid chromatograph ion trap tandem mass spectrometer (LC/MS). This equipment will enhance research in a number of areas including a) studies on radical reactions of transition metal-polyene complexes; b) methods for carrying out allylation reactions with allyl palladium complexes with high enantioselectivity; c) studying the mechanism of action of anti-cancer compounds closely related to the commonly prescribed drug, cisplatin; and d) studies of the Maillard reaction.Liquid chromatography with mass spectrometric detection (LC/MS) is an extremely powerful technique used for the separation and analysis of complex mixtures. This instrument will substantially strengthen scientific research at Middlebury College, a primarily undergraduate institution. These studies will have a solid impact in the area of synthetic organic chemistry and medicinal chemistry.

通过这项来自主要研究仪器（MRI）项目的奖励，米德尔伯里学院化学和生物化学系将获得一台液相色谱仪离子阱串联质谱仪（LC/MS）。该设备将加强若干领域的研究，包括a)过渡金属-多烯配合物自由基反应的研究；B)与具有高对映选择性的烯丙基钯配合物进行烯丙化反应的方法；C)研究与常用处方药顺铂密切相关的抗癌化合物的作用机制；d)美拉德反应的研究。液相色谱质谱检测（LC/MS）是一种非常强大的技术，用于分离和分析复杂的混合物。该仪器将大大加强米德尔伯里学院的科学研究，这是一个主要的本科生机构。这些研究将在合成有机化学和药物化学领域产生坚实的影响。