The Study of Molecular Asymmetry at Middlebury College

米德尔伯里学院的分子不对称研究

• 批准号: 9250157
• 负责人: Jeffrey Byers
• 金额: $ 1.14万
• 依托单位: Middlebury College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-05-01 至 1994-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9250157&HistoricalAwards=false
• 关键词: Study; Molecular; Asymmetry; Middlebury; College

The study of molecular asymmetry is being incorporated into the laboratory curriculum at four different levels: in the first semester introductory organic laboratory, students resolve optical isomers and prove chirality and measure optical purity using a polarimeter; during the second semester they synthesize secondary alcohols in enantiomeric excess and determine the isomeric ratios; in the advanced instrumental laboratories, enantiomers are resolved on a chiral HPLC column using the polarimeter as an HPLC detector; the chiral synthesis of (+)- disparlure, the Gypsy moth pheromone, is performed in an advanced organic laboratory. This equipment is also significantly enhancing undergraduate research in chiral synthesis.

分子不对称性的研究将在四个不同的水平上纳入实验课程：在第一学期的入门有机实验室中，学生分解光学异构体并证明手性，并使用旋光仪测量光学纯度；在第二学期中，他们合成对映体过量的仲醇并确定异构体比率；在先进的仪器实验室中，对映体在手性高效液相色谱柱上以旋光仪为检测器进行拆分；(+)-dislure的手性合成是在先进的有机实验室中进行的。这种设备也大大加强了本科生在手性合成方面的研究。